Prognostic Value Of Macrophage Colony Stimulating Factor In Risk Stratification Of Unstable Angina

Objective To investigate the prognostic value of macrophage colony stimulating factor(M-CSF) in risk stratification in unstable angina.Method Serum levels of M-CSF, tumor necrosis factor alpha (TNF α ), C-reactive protein(CRP) were measured using enzyme linked immunosorbent assay or particle-enhanced immunonephelomerty between 27 normal controls and 69 patients with unstable angina who were divided into Braunwald I , II, III group .The severity of coronary for the patients who were performed by coronary angiography were evaluated by a quantitative method.An event during hospitalization were observed in the three groups .Results The serum levels of M-CSF, TNF α , CRP increased from control group to Braunwald III group respectively(P<0.05).19 of 69 patients with unstable angina hadcardiac events during hospitalization.The incidence of eventful course was 8.3%, 28.6%, 45.8% respectively(P<0.05).1 1 patients with an event in Braunwald III group had higher M-CSF , CRP concentrations than those with uneventful course(P<0.05). Except M-CSF in Braunwald II (P<0.05)there is no appearent relation between serum levels of M-CSF, TNF α, CRP and severity of coronary stenosis(P>0.05).Conclusion The study demonstrates that there is a positive relation between the serum levels of M-CSF, TNF α, CRP and risk stratification in unstable angina while having no relation to the severity of coronary. Higher M-CSF, CRP concentrations can indicate an unexpected outcome of the patients in Braunwald III group.