Expression Of Estrogen And Progesterone Receptors In Pulmonary Carcinoma And Its Correlation Of Clinical Significance And Prognosis

Objective: To investigate whether estrogen receptors(ER) and progesterone receptors(PR) exist in the resected primary pulmonary carcinoma in human being and illuminate the link between the expression of ER and PR of the lung cancer tissue and its correlation of clinical significance .To investigate the expression of ER and PR which influence 3-year survival by retrospective study. Methods: 169 patients who had undergone resectable therapy for lung cancer between January 1998 and May 1999 were followed-up(end time was May 2002)to make certain how long the survival was and know the time and cause if the patients had been dead. The experimental group was 40 cases lung cancer(age range was 34～76 years old, median 53) who had result of follow-up. The control group consisted of 10 cases of resected pulmonary inflammatory pseudotumor and 20 cases of pulmonary inflammatory biopsy tissues by fibrobronchoscope and 10 cases of normal lung tissue from the patients without pulmonary carcinoma. S-P immunohistochemistry technique was applied to detect the expression of ER and PR in paraffine-embedded specimen. Corresponding clinical data were obtained from the medical record department of the first affiliated hospital of JiangXi Medical College. Results: (1). Patients had positive rate for estrogen and progesterone receptors in the lung cancer tissue is 62.5% and 47.5% respectively, but no evidence of estrogen or progesterone immunoreactivity was present in the control group. The positive rate of ER and PR was markedly higher than control group (P<0.01). (2). There was no significantinfluence of positive rate of ER and PR in the lung cancer tissue with pathological classification (P>0.05). (3). The ER and PR expression was not obviously associated with age and sex of lung cancer patients (P>0.05). (4). The differences of ER and PR expression in lung cancer with clinical stages were not statistically significant (P>0.05), but significantly related to the degrees of histological grading (P<0.05). (5).The tumor size and location was not significantly correlated with ER and PR level in those lung cancer patients (P>0.05). (6). Whether lymphatic metastasis or not wasn't found a statistically significant correlation of ER and PR expression (P>0.05). (7). There was no significant influence of positive rate between ER and PR (P>0.05). (8). The 3-year survival rate of patients with ER and PR positive was higher than those with negative (P<0.01). Conclusion: (1). It is demonstrated that ER and PR are present in lung cancer tissues with high expression. (2). There was a significant correlation between ER and PR positive percentage and degrees of histological grading in lung cancer, while ER and PR percentage appears to have no relationship with age, sex, pathological classification, clinical stages, tumor size, tumor location, and lymphatic metastasis of the patients. (3). The 3-year survival rate of patients with ER and PR positive was higher than those with negative.