Experimental Research On The Effect Of Tablet Qingrejieduhuazhuo On Rats With Injury To The Liver's Immunity

This animal experiment is to probe into the effect and mechanism of Tablet Qingrejieduhuazhuo on rats given BSA to induce immunity liver injury by observing rat's liver pathological change,ALT,HA,PCⅢ,CG,CH50,CIC,MDA,TXB2,6-Keto-PGF1αand so on,and to find out the best dosage of it.The results showed:1. Tablet Qingrejieduhuazhuo can markedly lower ALT,CG,yet,the big dosage of Tablet Qingrejieduhuazhuo can increase the level of TPR,ALB and PCⅢ in blood. 2. The big dosage of Tablet Qingrejieduhuazhuo have better effect on improve liver cell inflammation and hepatic fibrosis than the little dosage.3. Tablet Qingrejieduhuazhuo can lower the level of CIC,and increase the level of CH50 in blood.4. Tablet Qingrejieduhuazhuo can lower the level of TXB2,rectify the ratio of T/K,and the big dosage of Tablet Qingrejieduhuazhuo can decrease the level of MDA,increase the level of 6-Keto-PGF1α.Conclusions: Tablet Qingrejieduhuazhuo have pretty effect on protecting hepatocyte and reject hepatic fibrosis,and the effect of the big dosage is better than the little dosage.The mechanism might have anything to do with eliminating MDA,CIC,restraining CIC's activiating the complements and revising the dysequilibrium of TXA2-PGI2...