Association Of Latent Membrane Protein L And Matrix Metalloproteinase 9 With Metastasis In Nasopharyngeal Carcinoma

Objective: To evaluate the role of latent membrane protein(LMP) and matrix metalloproteinase(MMP) in the invasion and metastasis of nasopharyngeal carcinoma(NPC).Method: Forty cases of NPC were studied by immunohistochemical method using monoclonal antibody to LMP1 and MMP9.Result: It was showed that there were significantly correlation between LMP1 or MMP9 and the invasion and metastasis of NPC. The positive rate of LMP1 and MMP9 were higher in NPC with cervical lymph node involvement than that of no cervical lymph node involvement. The expression of MMP9 showed a significant positive correlation with the expression of LMP1.Conclusion: The results suggest that the induction of MMP9 by LMP1 contributes to the metastatic potential of NPC.