The Relationship Of Urinary Catecholamines Excretion To Ambulatory Blood Pressure In Type 2 Diabetic Nephropathy Patients

Objective: To study the relationship of urinary catecholamines excretion to ambulatory blood pressure in type 2 diabetic nephropathy patients. Methods: Daytime and nighttime urinary catecholamines [c(UCA)] including norepinephrine (NE) ,epinephrine (E) and dopaminc (DA) were determined by HPLC-EDA in 22 hypertensive (HDM group) diabetic nephropathy subjects.24h ambulatory blood pressure (ABP) profiles were recorded on the same day while urine samples were collected. Results: Daytime NE and E, nighttime NE and E, 24h NeandE in patients did not differ from subjects with paradoxical blood pressure rhythm and the remaining patients(P>o. 05). Canonical analysis showed no significant correlation between variables of UCA and indexes of 24h ABP setting(p>0. 05). However another finding of this study showed that daytime DA and 24h DA were significantly lower in HDM group than in nonpatients (P < 0.05). Conclusions: Sympathoadrenomedullary systems seem to have little significant contribution to the pathogenesis of diabetic hypertension and dysregulation of circadian rhythm of blood pressure. Diabetic nephropathy might play an important role.Decreased peripheral DA might be correlated todiabetic hypertension and diabetic nephropathy.