| Background and Objective: The present paper was based on a systemic research about the change of cardiopulmonary function of burned patients' with inhalation injury after nitric oxide inhaled. We measured the variables of cardiopulmonary function and reperfusion injury in order to find out the effect after nitric oxide inhaled and PS used in burned patients with inhalation injury. The possible principle was also discussed.Subject: 8 adult burned patients with middle-scale inhalation injury admitted within 8h following injury in two burn centers were divided into two groups in random. These patients had not suffered from cardiopulmonary disease. 4 patients in control group (C group) were treated according to the regular medical procedure and 10ppm nitric oxide. 4 patients in therapy group (T group) were treated according to the same procedure as that of control group and PS.Method: Swan-Ganz catheters were made use of in 8 patients. The age, total burned body surface area, burn index, fraction of oxygen concentration and the scale of inhalation injury of all patients' were measured. We also measuredpulmonary and cardiac function, hemodynamics and blood gas levels, superoxide dismutase, endothelin and total anti-oxide capacity and so on. The valued at baseline, 6, 12, 24, 48, 72 hours following injury. Stundent' test was used for the analysis of data.Results: 1. The value of baseline in two groups: the age, total burned body surface area, burn index, fraction of oxygen concentration and the scale of inhalation injury of all patients' in control group was similar to those in therapy group. This showed that the scale of patients' condition was same at the admission. Oxygenation index decreased. PA-aDO2 and Qs/Qt were increased. Cardiac output, cardiac index and stroke volume decreased. Systemic vascular resistance (SVR), mPAP and pulmonary vascular resistance (PVR) increased. These showed that cardiopulmonary function was inhibited early following injury. The activity of SOD and the concentration of MDA increased. The data showed that DO2I, VO2I and TAOC increased. These suggested that reperfusion injury took part in the process of lung injury following injury. The content of endothelin increased suggested that it maybe one of reasons why SVR and PVR increased early following injury. The variables of control group were almost same as that of therapy group at baseline (P>0.05).2. The changes of variables of pulmonary function intwo groups: â‘ Pulmonary function was improved. Oxygenation index increased, the value at 48h and 72h was significantly higher than that at baseline (P<0.01) in two groups. The values after 6h in T group were higher than that in C group, but there was not significantly difference (P>0.05). Qs/Qt declined, the values in T group decreased sharply after 12h compared with its baseline (P<0.01), and it was lower in T group than that in C group at 72h (P<0.05). The value of PA-aDO2 in two groups showed a decreasing-trend. The values after 24h were significantly lower than those at baseline in two groups (P<0.05, P<0.01). There was not significantly difference between two groups (P>0.05). â‘¡The change of hemodynamics. The value of mAP in two groups increased, the values after 24h were significantly higher than those at baseline (P<0.05, P<0.01). There was not significantly difference between two groups (P>0.05). The values of mPAP decreased significantly after 6h in two groups compared with each baseline (P<0.05, P<0.01). The values in T group after 6h were significantly lower than that in C group (P<0.05). SVR in two groups showed a declined trend, but there was not significantly difference between them (P>0.05). The values of PVR in two groups decreased gradually. The value in T group after 6h was significantly lower than that at baseline (P<0.01). The value in C group after 12h was significantly lower than that at baseline (P<0.01). After 6h, the values in T group weresignificantly lower than those in C group (P<0.05). â‘¢Cardiac function was improved.
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