Study Of Renin-Angiotension-Aldosterone System Activity In Healthy Offspring Of Patients With Essential Hypertension

Objective To measure the plasma concentration of Renin - Angiotensin-Aldosterone system (RASS) in Healthy offspring of patients with Essential hypertension (EH) and investagate the role of RAAS in EH.Method 60 Healthy offspring of patients with EH were recruited and dividedinto 2 group: 30 Healthy offspring of one parent with EH (one-parent group) and 30 Healthy offspring of parents with EH(parents group); 20 Healthy offspring of no family history patients with EH were recruited as the control group. The plasma concentration of PRA, ATII, ALD were determined by radioimmunoassay.Result1. The plasma concentration of PRA, ATII, ALD increase signifcantly in Healthy offspring of one parent with EH (p<0. 05) and parents with EH(p<0. 05, 0. 01, 0. 01) compared to those in the control group.2. There were no significant difference in plasmas concentration of APR, ATII, ALD between the healthy offspring of parents with EH and those of one parent with EH.3. There were positive correlation among the plasma concentration of APR and ATII, ATII and ALD, APR and ALD (r=0. 54 , 0.61, 0.50; p<0.05, 0.01,0.05).Conclusion1.The RAAS activity is probably increased in the healthy offspring of patients with EH.2. To some extend, Ell may be accosiated with some genes in RAAS.3. RAAS may play an important role in healthy offspring of patients with EH.4. The increased activity of RAAS may be regarded as an early risk marker for EH.