| Between May in 1986 and November in 2000, 174 patients with primary breast cancer were treated by breast-conserving therapy (BCT) in Tianjin Medical University Cancer Hospital. Their records, mammograms and pathological sections were reviewed. The purpose was to study the relative factors of local and distant failures after BCT retrospectively. The period of follow up was 12 to 196 months. The rate of follow up was 97.13%(169/174). Results: 1. There were 9 patients with local recurrence and 14 patients with distant metastasis. And 3-year recurrence rate was 3.79% (5/132);5-year metastasis rate was 10.99% (10/91); and 5-year survival rate was 92.31% (84/91). 2. 3-year recurrence rate for patients without radiotherapy (12.12%) was significantly higher than that with radiotherapy (1.01%), P<0.025. 3. In the group of patients with node-positive, 5 -year metastasis rate for patients without chemotherapy (44.44%) was higher than that with chemotherapy (6.67%), P<0.05. 4. Positive margin status was associated with local recurrence (P=0.0013). 5. Age at diagnosis of Patient with breast cancer (<40 years ), node-positive , grade 3histology were all highly significant factors of metastasis (p<0.05). The results showed that radiotherapy must be given after BCT; the patients with positive margin should be treated by reexcision or by mastectomy; the patients with young age,node-positive and grade 3 should receive adjuvant chemotherapy.
|
PDF Full Text Request