Sythesis And Characterization Of Glucosamine Derivatives And Their Complexes With Lanthanide

Based on the results of computer added drug design, a series of glucosamines with maleic anhydride derivative have been structural modifided and synthesized.This structural modification are comprised by (1) changing the protected groups of saccharide part to sythesize the compounds 2-amino- glucose linking with 3-formyl-propenoic acid with the deferent hydroxyl protected groups, such as acetyl, benzoyl, benzyl on saccharide; (Compound A, B andC) (2)change hydrogen bond donor and conjugate system in order to sythesizing the compounds 2-deoxyglucose linking with maleic acyl imide with the hydroxyl protected groups, acetyl, on saccharide and 2-amino-glucose linding with 3-formyl-propanic acid with the hydroxyl protected groups, acetyl, on saccharide, 2-amino-glucose linding with 2-formylbenzoic acid; (3)Deprotect those protected groups of saccharide in order to increasing their polarity, sythesize the compound 2-amino-glucose linking with 2-formylbenzoic acid; (4)change the spatial arrangement and the kind of sacchride, sythesize the compounds 1-ammo-glucose, 1-amino-galactose linking with 3-formyl-propenic acid with the hydroxyl protected groups, acetyl, on saccharide. Among of these compounds, A, B and C have been fostered their singal crystals which now is being testing their crystal structure. All compounds have been characterized by IR and NMR spectrum. The configuration of 1-bromido-peracetyl-glucose and 1-azido-peracetyl-glucose have been explained by anomeric effect and ortho-groups attached effect.Moreover, three series of Lantnide-sccharide complexes hve been firstly synthesized by the reaction of Lanthanide tricloride with the compounds d A , B as the ligand at the different ratio. The structure have been characterized by the NMR, IR and elemental aanalysis of metal and chloride. The distinction of the complexescharacters which have been synthesized by the saccharide including different protected groups and Lanthanide, have been discussed. The necessary preparation have been done to learn the mechanism of medicine in vivo by bio-probe effect of rare earth.Further determination of bioactivities of all comounds are currently researching. The singal crystals now is being fostering and testing their crystal structure.