Study On The Effect Of Obesity, Insulin Resistance, Level Of Leptin And Others On Blood Pressure In Some Male In-Patients

Objective: To study the effect of obesity, insulin resistance, the levels of insulin, leptin, uric acid and others on blood pressure in some male in-patients. At same time to explore if there was difference between the Hans and Uygers.Methods: Using the cross sectional method, we collected 115-in-patients (78 Hans, 37 Uygers) with essential hypertension admitted by the Department of Cardiology No.1 Affiliated Hospital of Xinjiang Medical University and 120-in-patients (76 Hans, 44 Uygers) without hypertension as a controlled group. Blood pressure and serum concentration of fasting insulin (INS), glucose (FBG), leptin (LEP), uric acid (Ur), total cholesterol (TC), triglyceride (TG), low dense lipoprotein (LDL), high dense lipoprotein (HDL) were measured; insulin resistance index (IR), body mass index (BMI) were calculated.Results: There were no significant difference of INS, TC, TG, FBS between hypertension and no-hypertension in Hans and Uygers men; BMI, LEP, Ur, IR were significant higher in hypertension patients than in no hypertension's. After grouped by nationality, the BMI and LEP in patients with hypertension were significantly higher than in patientswithout hypertension (P<0.01 and P<0.05) in two nationalities; and as same as Ur, IR only in Hans (P<0.05). In hypertension patients, Uygers had higher BMI than Hans (P<0.05); in patients without hypertension conclusion was IR (P < 0.05). Multiple linear correlation analysis indicates that a significant correlation between blood pressure and BMI, LEP, Ur, IR, INS in all men; the BMI and LEP were more significant than others; after further adjusting for BMI there were no correlations. There was same condition in Hans after grouped by nationality but LEP. There was a significant correlation between blood pressure and BMI, LEP in Uygers and not any correlation after further adjusting for BMI.Conclusion: The results had demonstrated again that there was vivo correlation between BMI and hypertension in adult men. INS had not significant association with hypertension although it had relation ship with BMI. LEP and IR have effect on human pressure, but this depended on BMI and had difference in race; the effect only existed in Hans and not in Uygers. Ur had significant correlation that being independent of BMI with hypertension in Hans, the mechanism of Ur to affect blood pressure maybe differentiated from that of LEP or IR. Among LEP, IR, INS, BMI and Ur had vivo relation ship.