| Jia wei tao he cheng qi soup is composed of tao he cheng qi soup based on traditional Chanise medicine book ({shang han za bing lun} and effective medicines chosed by our project group,along with the clinical experience.Objective: Multiple pathogenic factors were used to reproduce the fatty liver of rat. With dong bao gan tai tablets (another kind of medicine) as control medicine,we investigate the protective effect of traditional Chainse medicines on the fatty liver of rat and explore the mechanism of effects.The purpose of this study is to provide theoretical basis for clinic.Methods: According to the report,the 50 male Sprag-ue-Dawley rats were divided into 5 groups randomly, which were normal group,model group jia wei tao he cheng qi soup high dose group Jia wei tao he cheng qi soup low dose group and dong bao gan tai tablets control group, 10 rats every group. Except normal group,all the rats were treated with a low dose of Carbon tetrachlori-de(ccl4) and were fed on a low-dose of alcoholand a diet high in fat to produce fatty liver model. At the same time,drugs except normal group were fed to every group resprctivelyiThe rats of high dose group were fed on Chinese medicine liquid,which consisted of 24.48g crude drug/kg/d. The rats of low dose group were fed on Chinese medicine liquid which consisted of 12.24g crude drug/kg/d. The rats of control group were fed on medicine liquid which consisted of 0.33g crude drug/kg/d.The rats of normal group and model group were givin physiological salt solution. 15 days was continued. During the experiment,we observed their activities, diet, coat,and etc.On the Oth, 5th, 10th, 15th day, the body weight of all the rats were weighted. And on the 15th day,at the end of their treatment,all the rats were in the fasting state,and they were killed 12 hours later.Some data would be collected such as the concentration of serum total cholelterol(TC) and triglycerride(TG), the concentration of liver TC and TG,the activity of liver superoxide dismutase(SOD),the changes of liver pathological and so on.Result: During the experiment,the body weight in the normal group were increased,while decreased significantly in other groups. The activities of modal group were decreased,those of the treatment groups were better than model group.At the end of the experiment,all the rats intreatment groups almost regained the normal level.The result show, the liver volume of model group enlarged significantly,histological feature such as steatosis was observed.The treatment groups significantly improv?ed pathological display compared with model group.The change of the contents of serum AST wasn't obvious.On the contents of serom ALT,high dose group(18.30 ± 2.83),low dose group(20.10 ± 4.25) and control group( 19.40±6.98 ) were lower than model group (25.40 ± 5.88 , P < 0.05).On the concentration of serum triglyceride(TG),high dose group(0.80±0.24 ) was much significantly different from model group(1.16±0.23, P < 0.01),low dose group(0.84 ± 0.13) and control group(0.83±0.19) were different from model group(/*< 0.05).On the concentration of serum cholesterol(TC),high dose group(2.29±0.22),low dose group(2.50±0.37) and control group(2.35 ± 0.30) were all lower than model group(3.60 ± 0.32 , P<0.01).On the concentration of serum HDL,high dose group(1.67 + 0.24),low dose group(1.38±0.34)and control group(1.40±0.16) were all significantly higher than model group(1.02±0.31, P< 0.01). On the concentration of serum LDL,high dose group(0.40 ± 0.22),low dose group(0.79 ± 0.43)and control group(0.59 ± 0.32) were all significantly lower than model group(1.92±0.30, JP<0.01). On the resultsof atherosclerosis index,high dose group(0.43±0.21),low dose group(0.89 ± 0.50)and control group(0.69 ± 0.29) were all significantly lower than model group(2.82±1.08 , P<0.01).On the concentration of liver TC,high dose group(1.78±0.32) was significantly lower than model group(2.59±0.71, P<0.01),low dose group(2.01±0.60) and control group(1.97±0.52) were lower than model gro...
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