No.1 Pharmacokinetics Of Sustained Capsule And Tablet Of Aciclovir After A Single Oral Dose And Multiple Oral Doses In Dogs No.2 Pharmaeconomic Comparison Of Two Kind Of Therapeutics Ways In Pedo-asthma

No.l Pbarmacokioetics of sustained capsule and tablet of aciclovir after a single oral dose and multiple oral doses in dogsAciclovir is a broad spectrum drug of antivirus polymer of DNA ,it can prevent synthesis of DNA of virus, It is 160 time better than AC-1075,and have inhibition to chickenpox, herpes zoster, mammoth-cells virus, E-B virus. It is used extensively to treatment Herpetic keratitis, herpes simplex, herpes encephalitis, herpes bandlike and so on. The half life of aciclovir tablet is breve, and preclud is swif,and taking medicine 5 times everyday,200mg everytime. In order to evaluation difference of absorption of tardyfree capsuls and tablet, we developed pharmacokenitics investigarion of aciclovir tardyfree capsuls and tablet.The concentrations of aciclovir were measured by HPLC after a single oral dose and multiple oral doses. Experimental design is random crossing. In simplex dosage take tardyfree capsuls 27Smg and tablet 300mg; In multi-dosage take tardyfree capsuls 550mg everytime, two times everyday and take tablet 500mg everyday, five times everyday. The experiment procee for seven days.The concentrations of tardyfree capsuls rise slow and change steady in single dose. The concentrations is 0.2-1.4 ug.m;-1 in 2.5-12h, it is nearly 4 times overtablets. Cmax of tardyfree capsuls is 1.20+0.14ug.ml-1, Tmax is 4.67+0.41h. And Cmax and Tmax of tablets are 2.19 +0.19 ug.ml-1, 3.5+0.78h. Tmax,Cmax ofsingle dose are difference significant by pairing t-test.In multiple doses investigation tardyfree capsuls is transparent tardy. Thepharmacokinetic paramete of Cmax , Cmin , R, DF of steady state are 1.42 + 0.63 ug.ml-1, 0.93+0.36 M g.ml-1, (1.52+0.15)%,(46.61 +29.34)%. Tmax, R, DF of multiple dose are difference significant by pairing t-test.Releas experiment is reasonable by assay. It can reflect absorption and clinical effect in vivo of aciclovir tardyfree capsuls. The paramete can describe the law of dissolve and releas in vitro of tardyfree capsuls.It coincidence Weibull model. The releasing mechanism is possible mixed type (no-Fick diffuse mechanism), it is synergistic action of diffuse and bulk erosion of drugs.Releas experiment in vitro and pharmacokinetics in vivo have correlation by W-N and numeric value convolution and deconvolution.NO.2 Pharmaeconomic comparison of two kind of therapeutics ways in pedo-asthmaPharmaeconomic is a kind of science of describe health care system and cost price of social drug treatment, it is a kind of science that evaluating cost price of drug treatment.The entity of pharmaeconomic is contrasting drugs or serve and the produce of the-drugs or serve, by this way to definition which program is the best.The treatment of childhood asthma are inpatient care and follow-uptreatment of medical doctors. This topic comparison the two ways by cost-minimization analysis(CMA) and cost-utility analysis(CUA).In CMA , to statistics physic cost of outpatient and inpatient of childhood severity asthma of September 1999 to May 2000.In CUA, to statistics ICUR of outpatient and inpatient of childhood severity asthma of May 2000 to April 2002. The cost price and utility of outpatient treatment is lowest by two method.