The Study Of Metabolism Of Protein And Minerals For Cancer Patients Receiving Radiotherapy And The Effect Of Protein Diets Support On Immunity Function

Objective: The nutritional status of neoplasm patients will be affected when they receive local radiotherapy. In order to know the nutritional status and protein metabolism of these patients and to elaborate the effects of high protein support for these patients, we carried out a nutrition survey and a nitrogen balance test. Meanwhile, in order to find out the effect of high protein diet on immunity function of patients who receive the radiotherapy, we give high protein diet to patiets for one month after finishing the radiotherapy to observe the change of immunity function. At the same time, we determined the Ca and microelements Fe, Zn, Cu, Mn in foods ,urine and stool in order to know the characteristics of element intake and excrete.Methods: A twenty-four hour retrospective investigation was used for nutrition survey, Nitrogen was determined by Kjeldahl method, Ca and microelements are determined by AAS, Cellular immunity was determined by APAAP, Humoral immunity was determined by transmission method. Results:(l)The intake of calorie was lower than consumption, even if patients intook more calorie than RDA, it suggests that caloric requirement of cancer patients who receive radiotherapy is higher than RDA. During the radiotherapy, the body weight decline in most patients because of high consumption and lower intake of calorie and protein, The intake of vegetables, Vitamin A, B and elements Ca and Cu are lower than requirement.(2) The cancer patients were in the state of severe negative nitrogen balance beforeand after radiotherapy, The changes of nitrogen intake and excrete of urinary nitrogenwere not significant, It suggests radiotherapy has little effect on urinary nitrogen ofcancer patients. Excrete of stool nitrogen was higher than common people, It suggeststhe digestibility of protein is even poor.(3)After radiotherapy, The intake and excrete of elements decrease obviously afterradiotherapy.(4)The percentage of CD3, CD4 of the patients is lower than the control. Afterradiotherapy. CD3, CD4 and IgA decrease continuely, It suggests local radiotherapycan damage patients' immunity function.(5) The immunity function of patients who receive one month' nutritional support wasimproved obviously after finishing radiotherapy, but was still lower than the control.The patients who do not receive nutritional support had no change in their immunityfunction. It suggests high protein diet is good for immunity function improvement.