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Study On The Immune Mechanism Of Anti-Tumor Effect Induced By Total Gl Of Chishao

Posted on:2003-02-13Degree:MasterType:Thesis
Country:ChinaCandidate:M Y WuFull Text:PDF
GTID:2144360065460117Subject:Integrative basis
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Radix Paeoniae Rubra is an important Chinese herb activating blood flow and removing blood stasis(huo xue hua yu), usually used in the treatment of tumor and blood stasis, especially in the treatment of liver diseases as a component of traditional decoctions and modifying modern clinic decoctions.Based on the elementary research data of Radix Paeoniae Rubra and valuable ingredients isolated from it, we suppose that one of the chief components-the glucosides of CHISHAO(TGC) should be related to the anti-tumor effect of Radix Paeoniae Rubra. This study adopted loaded S180 cells mice model as an object of research and proved the anti-tumor effect of TGC; furthermore, explored the effective anti-tumor mechanism through study on its immune-regulation function.Our study showed the TGC can promote significantly the proliferation of mice splenocytes and the expression of CD8+ factor; activate the NK cells; increase the production of cytokine IL-2 and TNF- a ; has no influence on the expression of CD4+ factor.On the data mentioned above, we suggest that TGC possesses anti-tumor effect by promoting the proliferation of MHC restrictive cells CTL^ the expression of CD8+ factor to regulate the rate of CD4+/CD8+ to normal and improving the production of cytokine IL-2^ TNF- a to correct the phenomenon of Thl/Th2 drift. So TGC is an important and effective ingredient of Radix Paeoniae Rubra intumor inhibition.
Keywords/Search Tags:Huo Xue Hua Yu, Total glucosides of Radix Paeoniae Rubra, Tumor-immune function
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