The Effect Of Lipo PGE₁ On The Treatment Of The Elderly Patients With Low Extremity Atherosclerosis Disease

Objective: To investigate the effects of the Lipo-PGEi and the state of the microcirculation on the elderly patients with Low Extremity Atherosclerosis Disease (LEASD) by observing the alterations of clinical symptoms, ankle/ brachia index (ABI), Laser Doppler Perfusion Imagerofdorsum pedis ,nail fold microcirculation and hemorheology.Methods: 36 Male LEASD patients with mean age 68.5?, 5 years(60~93) were selected from inpatient of 301 hospital during March 2001 and January 2002. The alterations of clinical symptoms, ankle/ bsrachia index (ABI), Laser Doppler Perfusion Imager of dorsum pedis, nail fold microcirculation and hemorheological markers , liver and renal function, TG,TC,blood routine and urine routine were observed in the 36 patients of LEASD before and after treatment with Lipo-PGE,10 micrograms per day for 14days. Statistical analysis was performed using Stata 4.0 software.Result : After treatment , clinical symptoms, ankle/ brachia index (ABI), Laser Doppler Perfusion Imager of dorsum pedis were improvement significantly .The nail fold microcirculation total scores was decreased prominently (p<0. 01).the blood viscosity was decreased as well (p<0.05), ankle/brachia index (ABI), Laser Doppler Perfusion Imager of dorsum pedis were obviously improved , There were no significant differences in triglyceride, Cholesterol, liver and renal functions, blood and urine routines before and after the treatment(p>0. 05).There was no significant side effect during drug therapy.Conclusion: The Lipo-PGEi could improve the clinical symptoms , the nai fold microcirculation and decrease blood viscosity of the patients with LEASD . It is the medicine of safety, effect and prosperity to treat the patients with LEASD .