A Pharmaceutical Study On The Inhibition Of Prostatic Hyperplasia By Seeds Of Brassica Alba

This paper is a study on the extraction, separation, and content determination of all kinds of chemical components in seeds of Brassica alba. It also discusses the pharmacological effect and their mechanisms on BPH. The experimental methods and results are as follows.First, decide the optimal extract conditions of all kinds of extract.Second, seperate sinalbin, sinapine, 3 -sitosterol, from extract of Brassica alba's seeds.Third, use HPLC to measure the content of P -sitosterol; use GC and GC-MS to analyze and measure the component and content of fatty acid in ether extract of Brassica alba's seeds , the component and content of amino acid in seeds of Brassica alba are also analyzed and measured.Fourth, the medical effect of extracts and monomers obtained are filtrated using animal experiment of castrated mice prostatic hyperplasia induced by exterior hormone, several extracts and monomers which can significantly inhibit mice prostatic hyperplasia are found.Finally, by referring to the penetrability of capillary vesseK the hyperplasia of flesh bud and the activity of ACP and 5 a -reductase etc, the pharmacological mechanism of components inhibiting BPH are discussed.