| Degeneration of articular cartilage was regarded as one of the reasons of knee joint pain and charonic disability. Osteoarthritis was ranking second only to cardiovascular disease as a cause of chronic disability. The clinical importance of osteoarthritis will increase further as lift span increase; because the prevalence of osteoarthritis increase with age .The purpose of our experiments was optimized the parameters of different FE sequences. In order to improve the detection of articular cartilage abnormal and provide more helpful information for the clinical management.Parti Optimize the parameters of MRI different FE sequences of articular cartilagePurpose: We used different TE time combine with different flip angles, to find the best for depicting cartilage structure, and achieved the optimization parameters for different FE sequences.Materials and methods: Two ptoma knees were imaged with a 1.5T MR system. Optimization of the gradient echo sequences: 3D FAST(3D Fourier-acquired steady-state technique); FS+3D FAST; 3D RF-spoiled FAST(3D RF-Spoiled FAST);FS-I-3D RF-spoiled FAST was achieved by varying the flip angles of both gradient echo techniques(20 ??40?, 60?) and combining each flip angle with a different echo delay time (TE) (5 ^10,15, and 20 ms) .FS 3D FAST was not include TE=5ms, because of our MRI system limitation.This gave a total of 9orl2 different imaging parameters for each gradient echo technique. Then the contrast-to-noise(C/N) ratios for cartilage versus bone marrow and cartilage versus liquid were calculated. The statistic analysis was accomplished with SPSS software.Results: The best C/N ratio of cartilage versus bone marrow and cartilage versus liquid were achieved with the combination of TE=10ms and flip angle=60?in FAST sequence with spectral fat saturation; TE=5ms and flip angle=40?in RF-spoiled FAST sequence with spectral fat saturation.Conclusions: The optimization parameters in FS 3D FAST were TE=10ms, flip angle=60 ?and those in FS 3D RF-spoiled FAST were TE=5ms flip=40 ?PartH MRI of articular cartilage degeneration and correlation with histologyPurpose: Comparison of MR sequences in quantifying in vitro cartilage degeneration hi osteoarthritis of the knee with histology in order to conclusion the optimization MR sequences for articular cartilage degeneration.Materials and methods: Nine ptoma knees were imagied with 1.5 T MRI system. Seven different MR sequences were performed to each knee .The sequences included: FS 3D FAST, FS 3D RF-spoiled FAST, 3D FAST, 3D RF-spoiled FAST, SE TiWI, SE T2WI, SE PDWI. Then compared the number of lesions anddegreed of each sequence with histology results. The statistic analysis was accomplished with SPSS software.Results: The sensitivity of FS 3D FAST and FS 3D RF-spoiled FAST was92% and 95%. These FS 3D FE sequences were significantly better than other sequences (p<0.05). There was no significant difference between FS 3D FAST and FS 3D RF-spoiled FAST (p>0.05).Conclusion: T,WI 3D RF-spoiled FAST and T,WI FS 3D FAST imaging are both accurate for the defection and grading of articular cartilage abnormalities of the knee joint.PartfflMRI of abnormalities of human articular cartilage in the knee: comparison witharthroscopy.Purpose : Definite the useful of fat-suppressed three-dimensional gradient echo imaging for detecting hyaline cartilage defects of the knee, using arthroscopy as the standard of reference.Materials and methods: Twenty-seven patients (18 man and 9 woman, age range 27-70 years, mean 56 years)who underwent subsequent arthroscopy because of injury of meniscal and cruciate ligament or because of persistent symptoms of knee pain or locking were taken the MR examination. The MR sequences include SE TiWK FE T2WK FS 3D RF-spoiled FAST. Then they were taken arthroscopy within two weeks.Results: For the detection of abnormal articular cartilage of knee joint with FS 3D RF-spoiled FAST sequence, Sensitivity was90%, specificity was 98%andaccuracy was 96%, 90% lesio...
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