A Study On Specific CTL Response To LMP1-petides Within Nasopharyngeal Carcinoma Patients

Objective To analys the relationship between risk of nasopharyngeal carcinoma and human leukocyte antigens. And evaluate the specific CTL response to LMP1 within nasopharyngeal carcinoma patients. Methods The HLA-A2 locus from both healthy donors and NPC patients was detected by PCR-SSP assay. HLA-A2-positive nasopharyngeal carcinoma and normal control populations were analysed by ELISPOT assay to quantify frequencies of CTLs specific for LMP1 epitopes, using 2 HLA-A2-restricted petides derived from LMP1 as stimulators. Results There are no statistic significance between the HLA-A frequencies of NPC patients and control groups. Within NPC patients, frequencies of CTLs specific for LMP1 epitopes is lower than that of normal controls. Conclusion The HLA-A2 locus may have no association with the susceptibility to NPC. The specific CTL response to LMP1 within nasopharyngeal carcinoma patients is lower than that within normal groups.