Research Of The Relationship Betwwen Proliferative Activity And Prognosis In Adenoid Cystic Carcinoma Of The Salivary Glands

Adenoid cystic carcmomas(ACC),constituting approximately 20% of malignant Salivary gland tumors, is an elusive tumorcharacterized by aggressive growth and distant metastasis . The rate of DM stand first on the list of malignant tumor in maxillaofacial and oral cavity . Research in Proliferative activity, which is the base of infiltration and growth, can provide prognostic imformation in clinic.Objective: This paper reviewed relative literatures and studied proliferative activity in SACC section with immunohistochemical method in order to investingate the relation between malignancy degree, prognostic and SACC proliferative activity.Material and methods: 42 ACCs were retrived from the pathologyic files of Department of Oral and Maxillofacial Surgery,stomatological college , The Fourth Military Medical University and the third hospital of PLA in 1984-1999. PCNA, p53, Cath-D tests and AgNORs quantification study were perfonned.Their relationship with distant metastasis,regional recurrence, histopathologic type, clinical staging were discussed. Data were statistically analyzed by SPSS 10.0.Results: The expression of PCNA and the mean numbers of AgNORs pernucleus(mAgNORs) have significant relation with distant metastasis of SACC (P< 0.0l,P < 0.05)and histopathologic type, PCNALI and mAgNORs was higher insolid than in cribriform/tubular(P < 0.05). the expression of cathepsin-D werecorrelated positively with distant metastasis (P < 0.05),the expression of P53were correlated negative with clinical marker.(P > 0.05).conclusions: 1 PCNALI and mAgNORs may be one of the most usefulprognostic factor of ACC. 2 Cathpesin-D may be one of the most usefulprognostid factor of SACC ,the mutational change in P53 may be unimportant inthe development of SACC.3 The detection of proliferative activity in SACC mayplay an important role in diagnosis malignancy degree.