The Beneficial Effects Of Octreotide On The Lung Injury In Severe Acute Pancreatitis Rats

[Objective]: To investigate the possible beneficial effects andthe mechanism of octreotide on the lung injury severe acutepancreatitis rats.[Methods] The experimental rat model of severe acutepancreatitis was induced by retrograde cholangiopancreatic ductinjection of 5% sodium taurocholate. 63 male sparage-dawley ratswere divided into sham operation group(n=21), SAPgroup(n=21),octreotide therapy group (n=21).The production of NO in blood serum and the lung tissues, wet/dry lung weight ratio and Pao2were measured to evaluate the beneficial effect of octreotide on the lung injury in SAP rats, the expression of iNOS in the lung was also characterised immunohistochemically.[Results]Compared with the sham operation group, the wet/dry lung weight ratio markedly increased, the production of NO markedly increased especially at the 12 and 24 hours time point and Pao2 marked decreased in SAP group 0 Compared with SAP group, The production of NO in the lung tissues was markedly decreasedand pulmonary edema and the inflammatory cell infiltration in the lung were markedly alleviate in octreotide therapy group. Using immunohistochemical S-P method, the expression of iNOS was found in the vascular smooth muscle cell and the endothelium cell of the lung in SAP group.The expression of iNOS was not found in the lung of sham operation group. The expression of iNOS was weaken in octreotide therapy group .[Conclusion]:The down regulated iNOS expression and the decreased over production NO may contribute to the beneficial effects of octreotide on the lung injury in SAP rats.