| Objective: To investigate the expression of PTEN protein and Bax protein in extra-hepatic cholangiocarcinoma and the relation between their expression and clinico-pathological parameters .Methods: PTEN and Bax protein was analysed in 56 extra-hepatic cholangiocarcinomas, including 31 matched tissues originating from non-tumorous bile duct tissue adjacent to tumours and 6 normal bile duct tissues, by immunohistochemistry SABC. Results: There was significant difference of expression of PTEN between carcinoma ( 32/56) and noncancerous ( 26/31) specimens (p<0.05). Depression of PTEN in extra-hepatic cholangiocarcinoma was related to it's lymph node or distant organs or tissue metastasis (p<0.05), and the tumour differentiation degree (p<0.05). The positive rates of Bax expression in extra-hepatic cholangiocarcinoma and their matched tissues were 84%(47/56) and 55%(17/31) respectively, Their difference was significant (p<0.01). There was significant difference of expression of Bax in the tumour differentiation degree( P < 0. 005) .Conclusion: The expression level of PTEN may play a crucial role in the carcinogenesis and development in extra-hepatic cholangiocarcinoma, indicating that PTEN may provide a targetfor the gene therapy for extra-hepatic cholangiocarcinoma. |
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