Expermental Studies About Kidney Protecting Decoction Preventing The Kidney Senility

EXPERMENTAL STUDIES ABOUT KIDNEY-PROTECTING DECOCTION PREVENTING THEKIDNEY SENILITYABSTRACTKidney is an important organ of human body, it takes great effect in stabilizing the internal environment. Traditional Chinese Medicine thinks it stores the essence of life and is concerned with reproduction and the development of human body. The growth and development, then the senescence and death of the body depend on kidney-qi's growth and decline, ebb and flow. The kidney senility contains the progress of development and senescence of body, involves what the modern medicine say the decline of internal organ. Professor Luo Ji Jie thinks that asthenia of the kidney is the principal of ageing and blood stasis is the subordinate, deficiency in origin and excess in superficiality. Asthenia of the kidney and stagnation of the blood have mutual causality and mutual influence. This two aspects summarize the pathogenesis of ageing. Professor Luo made his empiric formularies "kidney-protecting decoction"according to his perennial clinical experience. This recipes can improve many decline-symptoms in clinical practice, such as:polyuria at night, ache and weakness of the lumbus and knees, vertigo and tinnitus, failing memory, senile plaque, and so on. It is proved that kidney-protecting decoction could protect the function of kidney. In this experiment, kidney-protecting decoction took effect in protecting kidney ageing at morphology. We intend to reveal the pathogenesis.1Experimental StudySelect 45 thirteen months old Wister mice, the male are 24, the female are 21. Separate them into three groups: Chinese herbalmedicine group, western medicine group, and model group. Taking 16 young Wister mice as young group. Inject D-lactonic acid into hypoderm as 80 mg/kg/d to make animal model. Feed mice of Chinese herbal medicine group with kidney-protecting decoction, mice of western medicine group with vitamin E, and model group with distilled water. After 2 months, kill the animal, observe the renal pathological section, survey the viscosity of blood. Result: 1. Kidney-protecting decoction can reduce the decline of old mice weight. 2. Reduce the viscosity of blood. 3. Optics microscopic observation: In Chinese herbal medicine group, the section of glomerulus is large, the glomerulus distribution is closer than that of others?group, the congestion in glomerulus is more obvious, atrophy and early fiberfill of glomerulus are few, and no protein cast is found in renal tubule. Kidney-protecting decoction can prevent Bowman抯 space from dilatation, and the amount of nephron from reduction 4. Electric microscopic observation: In Chinese herbal medicine group, the increase of glomnerular basement membrane is less than that of others?group, no tramtracking is seen, the fenestration of endothelial cells is regular, the arrangement of foot processes is in evenly order.2 ., DiscussKidney-protecting decoction can prevent the form and structure of kidney from ageing in several aspects: 1. Kidneyprotecting decoction takes effect in protecting the filtrated barrier of capillary tuft. 2. Lessen the occurrence of glomerulus fibrosis, tubules fibrosis, and interstitial fibrosis. The reason is that kidney-protecting decoction can make the blood in capillary tuft plentiful, then gradually restore retrogressive change of early cell denature and atrophy due to blood depletion and oxygen depletion.4The reason also relate to inhibiting the occurrence of antigenantibody compound, preventing the immune associated compound from depositing at glomerular basement membrane. Therefore, kidney-protecting decoction is considered having the capacity of regulating immune and delaying senility.