An Preliminary Study Of The Effects Of Combined Oral Contraceptives And Gene Polymorphism On Stroke

Cardiovascular disease is the seldom and serious adverse effect dining using combined oral contraceptives(COC). Recently some researches show that women using COG have an increase risk of cardiovascular disease such as myocardial infarction and stroke if they are over 35 years old, smoking or being hypertension synchronously. Owing to the diversity of cardiovascular disease morbidity resulted from the differences between China and other countnes, it is not sure whether the conclusions drawn from those countries are correct in China. It is argued that the genetic and the environmental factors underlie the onset of the cardiovascular diseases. Therefore, we should evaluate risk factors including genetic and nongenetic factors(pili-use and other factors) so as to study these disorders related to COG. In this study we selected some stroke women patients in Rudong and Taichang counties of Jiangsu Province and discussed the genetic and nongenelic problems of the patients. Part I Study on the Relationship between Combined Oral Contraceptives and the various types of Stroke We selected the women who suffered from the first stroke seizure during the time from October 1, 1998 to April 30, 2000. A questionnaire was carried out to get their detailed information. These data were analyzed by case-case study. The results show as follows: 1. 111 stroke patients were collected during this time, including 50 COC-user(45.05%). The major type of pills was homemade OC Ill (combined norethisterone, accounting for 76% of all users). 68% of users had a drug-use histomy for more than 60 months; Most users had stopped using COG for over twenty months when their stroke happened. 2. Case-case study. All patients were divided into two groups on account of occlusion or hemorrhage. The result of univariate and multivariate Logistic regression analysis showed that women using pills had a higher risk in hemorrhagic stroke than in ischaeniic stoke(P