| Heatt Failure (HF) is a common and serious clinical s~ndtone that deadly impairs people?s health. It is not a single disease, but the final stage of all kinds of cardiac desease. Its morbidity is high, and its surviral rat within five years is similar to that of malignant tumor. It is very important to defend the health of human being k inquiring into the pathologic mechanism and finding the ways for treat ing CE-fF. ha ix iii i capsule is the pat ient medicine iit~ented by Pt o. Clien. j inghe of the First Atfi I iated Hospital of Guangzhoii Uni ~ts it v of ThM, wh icli is clinical lv used to cu~ e the asyrnptomat ic tteurt ta i lure and HF patient of NYHA I or II ,and have very good effect. In order to prove the mechmtisw of it?s good effect, we did some research from t~o big aspect, the theory research and the animal experiment: the theory research 1. the theory research of TCM in HF There is not a identical conclusion about the name, pat.hogenesis and treatment for CHF in traditional Chinese medicine (TCM). Generally it is iiicltided in such categosies as syndrone of dyspnea, palpitation, edema and so on. It is considered that the basic pathogenesis of CHF is blood stasis due to deficiency of qt and edema due to deficiency of yang. Deficiency of qi and yang is the origin, which blood stasis and edema are the superficiality. It involvesthe four organs: heart, kidney, lung aad spleen. The basis principle of treatment is supplementing qt, activating blood circulation, invigorating yang and dimes is. 2. the theory research of West梞edicine in HF: A. The strategy of curing HF of the world has change as this : safeguard the heart, real the HF pitt iettt befox e the congest rye semiotic has appeared , with the ultimate target of better-went of the quality of living, prolong the livability of the patients. B. A twpot tant transit ion of the HF conception is asymptomat.ic heart failure?s appearance (AHF). AHF means that a patient who has had the hoist of the LVEDP ,but has none symptom. AHF is the stage more lighter than the HF NYHA I. The state of this disease looks very stable, but it.?s a fakement. Actually , thete are a lot of pathiophystologtcal changes evolving at this state such as entricular 5 ~fr~5:. I 4i~5iUML-~5 t~5 ~?~ 閪 remolding and myocardial remolding. It will soon or later translate into congestive heart failure. C. The definite pat.ho~)hysiological mechanism of UHF is not very clear yet. Now it. is considered that the main reason that causes UHF to be exacerbated from adaptation to maladjustment is the decrease in amount and the change of quail ty (structure and funct ion) of iuyocardial cells due to maiiv different reasons. The latest study found that apoptosis is one of the reasons that cause the decrease of myocardial cells and decline in the function of cardiac muscle. Recently the modern medical treatments for CHF have dcvel~ped from traditional methods, such as diuresis, dilatating !)lOOd vessels, using cardiot.onic and so on to many other ways, such as arousing negative inot.ropic action, antagonizing neurohormone, iiihibi t ing ventricular restructure and apoptosis of myocardial cells and so on. According to study of the above, we decide to use the achievement of apoptosis and neuroendocrine theory in the HF and do the experiment that can prove the...
|
PDF Full Text Request