Clinical Study On The Relationship Between Essential Hypotension,its TCM Pattern Types And Plasma Endothelin,Nitric Oxide And Other Factors

w ABSTRACT Background: Some chemicals in blood can modulate blood pressure by exerting an effect on cardiac myocyte and vascular smooth muscle, which may be involved in the pathogenesis mechanism of essential hypotension. Objectives: To provide modem laboratory reference for essential hypotension and its TCM types by researching the change of plasma endothelin(ET), nitric oxide(NO), adrenaline(E) and norepinephrine(NE), fasting plasma glucose(FPG), fasting insulin(FIN) and insulin sensitive index(ISI) level. Materials and Methods: According to WHO diagnosis criteria and TCM differentiation criteria. We selected 50 cases (18 male, 32 female) the average age is 36.07?7.52, among them 12 cases in liver-Qi stagnation group, 16 cases in Qi deficiency group, 10 cases in blood deficiency group and 12 cases in essence deficiency group. 30 healthy people (11 male, 19 female), were taken as the control group. Their average age is 34.12?8.46.We detected plasma ET by RIA method, NO by colorimeteric method, plasma E, NE by fluorimetric method, FPG, electrolytes by the glucose oxidase method, and take the reverse of the product of FPG and FIN as ISI. Results: 1 .Compared with the control group, the level of NO was very significantly higher than that in treatment group (PKO.Ol); the level of ET and the ratio of NO/ET increased significantly, too. 2.There were no obvious difference between the treatment group and the control group in the level of E and NE. 3.The ratio of Na~/K~ in treatment group was obviously higher than that in control group, which had statistic meaning. 4. The level of FPG, FIN increased significantly, which had statistical meaning.5. The level of NO in the four group were significantly higher than that in the control group and there were obviously difference among Qi deficiency group, essence deficiency group and blood deficiency group. 6.There were no significant difference among the four groups in the levels of E, NE, FPG, FIN, ISI and among the four groups and the control group.7. The level of K~ in the Qi deficiency group, essence deficiency group and blood deficiency group is lower than that in the control group, but there was no clinical meaning. 8.There was a close negative correlation between the blood pressure and NO, NO[ET, K~. 9.The main factors which affect diastolic blood pressure (DBP) is NO, FPG, Nat. The main factors which affect systolic blood pressure are NO, FPG, NE. Conclusion: The change of ET and NO level may play an important role in the pathogenesis of essential hypotension and may provide material basis for essential hypotension TCM pattern types and reference index of modem laboratory.