| In hepatocellular carcinoma with long chronic infection of hepatitis B virus , hepatitis B virus surface antigen is closely associated with the occurrence of hepatoma ; further more it can accelerate the growth of hepatonia cells and suppress their apoptosis through activating the gene of transforming growth factor a and some other transcriptional factors promoters ; transfer immunity against hepatitis B virus surface antigen can get the suppression of human hepatoma Use human anti-1{B sAg monoclonal Fab producted by the technology of gene engineering to affect two human hepatoma cell lines: HepG2 cell , without the expression of HIBsAg, and LlepG2.2. 15 cell,with the expression of HBsAg. Checking the effect with agar clone forming test and MT~ , we can see the Fab can suppress the growth of HepG2.2. 15 cell with the expression of HBsAg, and the suppressional effect can be enhanced by co-affect with 111-2 or a æ¡°FN. |
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