Effects Of Zearalenone And Adsorbent On Reproductive Development, Blood Biochemical Parameters And Histomorphology In Piglets

An experiment was conducted to study the effects of zearalenone with or without adsorbent addition on reproductive development, blood biochemical parameters and histomorphology in weaned piglets over a 24-day period. A total of thirty-five crossbred weaned piglets aged 35 days, with initial weight of 12.36±1.46 kg, were randomly allotted to seven treatments (five piglets per treatment). Treatments were 1) C1 = control; 2) C2 = control + 2.5 g adsorbent /kg diet; 3) E1 = control + 1 mg ZEA /kg diet; 4) E2 = E1 + 1.25 g adsorbent /kg diet; 5) E3 = E1 + 2.5 g adsorbent /kg diet; 6) E4 = E1 +5.0 g adsorbent /kg diet; 7) E5 = E1 + 10 g adsorbent /kg diet. The results are summarized as follows.When compared with C1 piglets, those receiving ZEA without adsorbent addition had higher (P<0.05) average daily gain (ADG), and had similar (P>0.05) average daily feed intake (ADFI), feed conversion rate (FCR), organ index and muscle routine composition. ZEA treatments with 2.5, 5.0, 10.0 g/kg adsorbent addition resulted in lower (P<0.05) ADG compared with E1 animals. Piglets received adsorbent alone reduced ADG and ADFI, but not significant (P>0.05).Piglets received ZEA without added adsorbent had lower (P<0.05) apparent digestibilities of energy and protein and apparent metabolic rate of energy. In E4 and E5 piglets, those values were higher (P<0.05) compared with E1 animals. Apparent metabolic rate of protein were similar (P>0.05) among all treatments.Dietary 1 mg/kg ZEA increased (P<0.05) vulva width, vulva length, vulva aera, absolute weight and relative weight of uterus, reduced (P<0.05) FSH, PRL and E2 concentration, and obviously excited follicular development. Diets with 5.0 or 10.0 g/kg adsorbent addition could significantly repair reproductive toxicity caused by ZEA administration.Animals received ZEA alone had lower (P<0.05) platelet, haemoglobin, globulin, triglyceride, HDL and Fe concentration, and higher (P<0.05) cholesterol, VLDL, urea, creatinine, AST, ALT, ALP, GGT, CK and CKI, and serious injury of liver and kidney. Adsorbent in 5.0 or 10.0 g/kg addition level evidently improved the effects of ZEA in piglets.Piglets exposured 1 mg ZEA /kg diet for 24 days showed serious reproductive toxicity, hepatotoxicity and nephrotoxicity, and had lower energy and protein utilization. Adsorbent could repair the damage caused by ZEA, and the most suitable added concentration of adsorbent in piglets diet with 1 mg/kg ZEA exposured was 5.0 g/kg.