The Study Of Changes In Endotoxin Concentrations Of Postpartum Uterine Infection And Treatment Of LPS To Uterine Infection In Goats

Uterine infection of dairy cows is a non-specific infection disease and one of the majordiseases in dairy cows after calving, which has great impact on the dairy industry. It can causethe decrease of the reproductive performance and the production, increase the treatment costand culling rate and result in great economic losses on the dairy industry.We constructed uterine infection models with the goat, which has close relationship withcow, aiming to provide methods for diagnosis and treatment of uterine infection in dairy cows.The objective of this study is to find the relationship between the concentration of theendotoxin in uterine and blood of postpartum goats (control) and uterine infected goats(treatment).The goats were divided into tow groups, treatment (n=8) and control (n=5). The experimentis consisted of two parts: first part, blood and uterine excretion were collected from dl to d20after calving and the concentration of endotoxin in samples were measured by the TAL.Second part, the amounts of PMNs in uterine excetion were counted after LPS injection as atreatment on uterine infection..The results showed that: the relationship between the content of endotoxin in uterineexcretion and postpartum uterine infection was significantly (P＜0.01) in uterine infeced goats,no matter to what extent; the bacterial endotoxin in blood has a certain relationship withpostpartum uterine infection while not significantlhy; LPS showed significantly effective as atreatment to uterine infection, through inducing the infiltration of lucocyte to uterine lumen.In conclusion, effective diagnosis and treatment of dairy cows is very important to thedairy industry. The result of this study indicates that the changes of endotoxin in uterinecontents highly related to the uterine infection and might become a potential indicator ofuterine infection in goats. And LPS showed certain effect on the treatment of the postpartumuterine infection in goats. These results provide one possible and potential method to carryout the further research on dairy cows.