Analysis Of Influencing Factors Of Extended Treatment After Routine Treatment Of Pulmonary Tuberculosis Patients And Monitoring Of Drug Resistance In

ObjectivesTo investigate the factors affecting the treatment of the patients with pulmonary tuberculosis after the treatment of the standard regimen.MethodsBy a case control study,828 patients treated in the outpatient department of Beijing Chaoyang District tuberculosis from January 2008 to December 2012 were analysised.it was including 564 males,264 women, age between 18-63 year old, average age was 39.23+19.5 years. According to the length of treatment time they were divided into a (589), B (245), C (18) three groups, and histological changes were observed in the 3 groups of patients with pulmonary imaging, through the medical records of each patient’s the gender, age, weight, lung lesions wild number, empty lung field number were analysis in order to observation of these factors on the prolongation of the treatment effect and recurrence of pulmonary tuberculosis patients in the standard treatment.ResultsAfter prolonged treatment and in 3 groups of patients were analyzed we found group B and group C lesions gradually absorbedafter prolonged therapy,three groups have obvious difference of factors including results of PPD test, newly diagnosed sputum smear amount (～+++++), combined with diabetes, lesions (void) lung field number. The or values were 4.952,5.985,2758 and 3.987.ConclusionsFor patients with chest radiograph was still active lesions and high risk factors, it can significantly improve the treatment effect of the patient through extending the TB treatment period. It can improve the effect of treatment for patients withthe elderly, extensive disease, multiple empty, lesions and diabetes.ObjectiveTo investigate the drug resistance of tuberculosis patients in Chaoyang District, Beijing, and drug resistance spectrum, in order to provide a appropriate treatment for clinical tuberculosis and tuberculosis prevention and control in the region.Subjects and MethodsThesamples was suspicious TB sputum in Beijing Tuberculosis outpatient departments from January 2013 to June 2014 in the Chaoyang District, it was including 410 positive strains. It was susceptibility tested by isoniazid (INH), rifampicin (RFP), streptomycin (SM) and ethambutol (EMB first-line anti-tuberculosis Drug through recommended by WHO LJ medium susceptibility testing proportion method, respectively,).ResultsThe overall resistance rate of 22.1%(88/399). SM resistance rate was the highest (16.3%), followed by resistance to INH (12.3%), anti-RFP (6.8%), the lowest rate of EMB resistance (2.5%),11 non-tuberculous mycobacteria were the four first-line anti-TB drugs in one or more of drug resistance, the total resistance rate was 100%, the patients with resistant retreatment rate was significantly higher than at the beginning of RFP treated patients, drug resistance rate had nothing with gender, age and population distribution-independent.ConclusionThere were a substantial proportion of drug-resistant TB patientsin Chaoyang District, Beijing, it had need to strengthen tuberculosis drug use management, good resistance analysis, to give a more rational drug programs to reduce the incidence of drug-resistant TB.