Effects Of Magnesium Sulfate On Fetal Blood Flow In Preeclampsia Patients

Objective To study the effect of magnesium sulfate on the fetal blood flow in severe preeclampsia.Methods A total of 66 women with severe preeclampsia were prospectively recruited and divided two groups, ≤30 week group(n=28) and >30 week group(n=38),according to the gestation age. Blood flow parameters,resistance index(RI) pulsatility index(PI),S/D ratio(S/D) examinations on the umbilical artery(UA), middle cerebral artery(MCA), uterine arteries(Ut A), were performed before and 8 hours after magnesium sulfate infusion,meanwhile,levels of serum magnesium and calcium were determined.Results There was a statistically significant reduction in RI,PI, S/D in Ut A and RI in UA,MCA in ≤30 week group(P<0.01). There was no statistically significant reduction in PI and S/D in UA and MCA in ≤30 week group(P>0.05). There was a statistically significant reduction in RI,PI and S/D in Ut A UA MCA in >30 week group(P<0.01).The levels of serum magnesium increased and the ratios of Ca / Mg decreased significantly after magnesium sulfate infusion(P<0.01).There was no correlation between levels of serum magnesium(or ratios of Ca / Mg)and blood flow parameters(P>0.05).Conclusion Magnesium sulfate may influence the fetal blood flow in severe preeclampsia,but the effect may have no correlation with levels of serum magnesium.