Effects Of Oxidative Stress On In Vitro Fertilization And Embryo Transplantation In Patients With Polycystic Ovary Syndrome

Objective: To investigate the effects of follicular fluid oxidative stress on the pregnancy outcome of patients with polycystic ovary syndrome undergoing in vitro fertilization and embryo transfer.Methods: Collected follicular fluid from 25 cases of patients with PCOS undergoing IVF-ET and 23 cases of the control group. Collected clear follicular fluid on the egg retrieval day, and tested a variety of oxidative stress-related indicators, such as MDA, AOPP,TAC, SOD, follicular fluid ability to inhibit hydroxyl radical(? OH), Co Q10, GSH, GSSG,etc.Results: Compared with the control group, a lower ability to inhibit the production of hydroxyl radicals and a low level of GSH/GSSG were found in PCOS group, the difference was statistically significant(P = 0.008; P = 0.036), and the PCOS group and control group in normal intrauterine pregnancy group GSH / GSSG levels were higher than those without access to normal intrauterine group, there was no difference of other indicators between the two groups.Conclusion: Oxidative stress has been found in patients with PCOS, and its influence may be involved in abnormal pregnancy outcome in vitro fertilization and embryo transfer.