Study On TCM Syndrome Differentiation Of Type 2 Diabetes Based On Data Mining Technology

Objective:Use data mining techniques and methods to study the medical record reported in the journal literature about Chinese herbal treatment of type2diabetes, and establish Traditional Chinese Medicine(TCM) syndrome differentiation regularity of Type2diabetes,which makes "four diagnostic information-syndrome factor differentiation-treating medicine" as a whole.Methods:Collect the journal literature of domestic and foreign periodicals about Chinese herbal treatment of type2diabetes from2004to2014, explore the modern TCM syndrome differentiation regularity of Type2diabetes by using data mining techniques, such as frequency statistics, cluster analysis, association rules and so on.Results:Through the data mining study of118type2diabetes literature, find the modern TCM syndrome differentiation regularity of type2diabetes base on the TCM theory, make some innovation and development, and reveal hidden treatment regularity.1. Lassitude, dizziness, thirsting for cold are the most common symptoms of T2DM, traditional "polyuria, polydipsia, polyphagia, weight loss" become Less and less. Type of tongue and pulse is less and type distribution is concentration, pulse condition focus on the veinlets and tongue focus on the pale tongue. T2DM common6categories syndromes:limb skin numbness, dark red tongue, astringent pulse; chest tightness, upset, greasy tongue, the tongue side with teeth marks, slippery pulse; body fat, languid, abdominal distension, anorexia, loose stools, edema, pale tongue, white fur, sunken pulse, feeble pulse; dizziness, shortness of breath, spontaneous perspiration, dry pharynx, weak waist, tinnitus, five frustrating heat, night sweat, palpitations, insomnia, red tongue, dry tongue, thin white fur, fur stripping, less fur, no fur, dry tongue fur, thready pulse, rapid pulse; emaciation, thirsting for cold, increased eating with rapid hungering, yellow urine, frequent urination, diuresis; edgy and irritable, bitter taste in mouth, thirst, dry stool, yellow tongue fur, pulse string. 2. T2DM common syndrome factors can be grouped into the following categories, the disease location mainly concerns heart, liver, spleen, stomach, kidney; disease resistance is mainly Qi deficiency, Yang deficiency, Blood deficiency, Yin deficiency, hot, wet, phlegm and blood stasis. The combination laws of syndrome and factor is①Kidney, Qi deficiency, Yang deficiency, blood deficiency②Yin deficiency, hot③liver, heart, Yang hyperactivity④stomach, Qi stagnation⑤spleen, wet, sputum⑥blood stasis.3. The common drug groups are:safflower, peach kernel, red peony root, Ligusticum chuanxiong hort, angelica, cauls spatholobi, Bupleurum, fructus aurantii, radix curcumae, Radix Paeoniae Alba; Radix Astragalus, windbreak, radix achyranthis bidentatae, motherwort, rhubarb, cassia twig, epimedium, concha ostreae; Radix asparagi, semen Ziziphi Spinosae, Salvia miltiorrhiza, Cortex Lycii, Cortex Phellodendri, cortex mori radicis, leech, Radix trichosanthis, Pueraria Lobata, radix rehmanniae, Rhizoma Anemarrhenae, gypsum, Rhizoma Coptidis, radix ophiopogonis, Radix Pseudostellariae, Schisandra chinensis, Radix Scrophulariae, polygonatum odoratum, Rhizoma Polygonati Odorati; Poria with hostwood, Radix Aucklandiae, Radix Scutellariae, gardenia, semen plantaginis; Perrin, gizzard pepsin, patchouli, Magnolia officinalis, Herba Lycopi, Dendrobium, Trichosanthes kirilowii Maxim, Radix liquiritiae, Radix Codonopsis, white atractylodes rhizome, coix seed, Amomum villosum, Platycodon root, ginseng, Fructus aurantii Immaturus, bamboo shavings, pinellia, Atractylodes rhizome, Poria cocos, tangerine peel tree peony bark, ginger; cortex moutan radicis, Rhizoma alismatis, Polyporus, medlar, dodder seed, aconite, cinnamon, Fructus Corni, yam, Radix Rehmanniae Preparata, Eucommia ulmoides Oliv.4. The relationship between drug and symptom:Astragalus-lassitude, berberine thirsting for cold, Poria-soreness and weakness of waist and knees, dogwood-soreness and weakness of waist and knees, licorice-lassitude, Poria-loose stools, radix ophiopogonis-thirsting for cold, Codonopsis-lassitude, Schisandra-lassitude, Anemarrhena-night sweats, berberine-insomnia, radices trichosanthis-thirsting for cold, Radix Rehmanniae Recens-thirsting for cold. Couplet medicines:oysters、keel, astragalus、yam, Poria. dogwood, gypsum、rhizoma anemarrhenae, Radix Ophiopogonis、Scrophulariaceae, radix puerariae、radices trichosanthis, Poria、yam, Astragalus、rhizoma polygonati, Salvia、kudzu root, angelica、red peony, berberine、 cinnamon.Conclusion:Through data mining research, we establish TCM syndrome differentiation regularity of Type2diabetes in literature-based, which makes "four diagnostic information-syndrome factor differentiation-treating medicine" as a whole.