Study On The Relationship Between The Expression Of GAS, MOT And SP In Reflux Esophagitis And Gastrointestinal Hormone By

Gastroesophageal reflux disease(GERD) is the most common disease,which is widely distributed in the Gastroenterology clinic.There is a large incidence rate in general hospitals and primary hospitals.Reflux Esophagitis (RE) is one type of GERD and characterized by chronic recurrent、long duration and difficult to cure,seriously deteriorated patient’s quality life.In recent years,Traditional Chinese medicine treatment has accumulated rich experience and madesignificant achievements,but still lack of evidence-based medical evidence to support.so it is necessary to do some in-depth study of the curative effect of prevention and control mechanism of traditional Chinese medicine.[Objectives]This subject is to carry out a clinical research of xinkaikujiang method to cure Gastroesophageal reflux disease(cold and heat mixed type),observing the clinical efficacy and safety of curing Gastroesophageal reflux disease(cold and heat mixed type) by using the formula of xinkaikujiang.It is intended to research the pathogenesis of GERD and curative effect mechanism of traditional Chinese medicine to provide new ideas and methods.[Methonds]Collecting the clinical information of the patients who was diagnosed GERD in the WangJing Hospital of CACMS from November 2013 to December 2014.Randomly selected 66 patients who meet the diagnostic criteria for RE,then divided them into treatment group and control group, each group had 33 cases.Treatment group received rabeprazole sodium enteric-coated capsules 20mg qd and oral administration of Chinese medicine decoction of xinkaikujiang formula granule 150ml bid; the control group were treated using rabeprazole sodium enteric-coated capsules 20mg qd and placebo formula granule 150ml bid.The process was about 4 weeks. We can examine the expression of GAS、MOT、SP in Reflux esophagitis patients’esophageal mucosa by immunohistochemistry,If there is a statistically significant compared with control group. We can examined the expression of GAS、MOT、SP in human esophageal mucosa by immunohistochemistry before and after the treatment. Observe 66 patients’the expression of GAS、MOT、SP in esophageal mucosa and the score of HAMA、 HAMD,clinical symptoms、endoscopy integral correlation between each other.Applying for SPSS 17.0 software,this study statistically evaluate its efficacy.[The result]1.With esophageal mucosa under gastroscope change degree of decision criteria for effectiveness,through the comparison of two periods,the total effective rate in treatment group is 72.7%,the total effective rate in control group is 51.5%,There were significant difference between the two groups (P=0.076> 0.05).Combined with project prophase research,the xinkaikujiang formula plays a significantly improved role in the patients which have the clinical symptoms.2.1n affecting the expression of MOT、SP before and after the treatment,the xinkaikujiang formula is more obvious than the control group.3.From the perspective of disease,there is no correlation between the scores of HAMA、 HAMD、clinical symptoms、gastroscopy and the expression of GAS、MOT、SP.4.From the perspective of treatment,After treated by the formula of xinkaikujiang,The scores of clinical symptoms were positively correlated with the expression of GAS.[Conclusion]1.The different degrees of gut hormones secretion level are exist in Reflux esophagitis patients.2.1t has better clinical efficacy by using the method of xinkaikujiang method in curing Gastroesophageal reflux disease(cold and heat mixed type),and significantly improve patients’clinical symptoms and mental state,The curative effect mechanism could be ele vated by esophageal mucosa MOT、SP gastrointestinal hormones secretion level.