A Case - Control Study On The Correlation Between Gastrointestinal Fever And Helicobacter Pylori Infection

Background:Helicobacter pylori is the pathogenic bacteria of an active gastritis. It is closely related to peptic ulcer, gastric mucosa related lymph tumors etc. and is a high risk factor for stomach cancer. Through clinical observations, there have been findings that gastrointestinal heat retention syndrome patients are prone to Hp infection. This suggests that gastrointestinal heat retention syndrome could have a correlation with Hp infection.Objective:To find a correlation between gastrointestinal heat retention syndrome patients and Hp infection through a case-control study, providing a basis for preventing Hp infection through the perspective of TCM etiology.To explore the correlation between gastrointestinal heat retention syndrome and Hp infection.Methods:1 Theory ExplorationBy researching and understanding ancient TCM literatures as well as modern literature, it is known that gastrointestinal heat retention syndrome refers to the pathogenic heat in the stomach and intestines, and mainly manifests with sumptoms such as flushing and fever, dry mouth, bad breath, preference to cold drinks, irritation, dry stool, yellow urine, red tongue, yellow coating and a fast slippery pulse. Such manifestations show similarities to the symptoms of the initial stage of Hp infection. Explore the correlation between gastrointestinal heat retention syndrome and Hp infection through literature research, giving a theoretical basis for clinical researches.2 Case-control StudyFrom October 2014 to December 2014, patients from the Gastroenterology Department of the Ministry of Health TCM Hospital were taken in based on the inclusion and exclusion criteria. They were then put into the Case Group and the Control Group, and were asked to sign an informed notification, and by using CRF forms, related information was gathered.According to the "Gastrointestinal Heat Retention Integral Diagnosis Scale", the syndrome was confirmed as an exposure factor. Patients with the syndrome in both groups were counted, and the exposure ratio was calculated, resulting in an Odds Ratio (OR). A Chi-square test was used for the equilibrium test between basic characteristics such as age, sex etc. between the patients; Logistic regression was used to analyze the risk factors of Hp. Excel 2010 and SPSS 20.0 was used to analyze the data.Results:By researching ancient and modern TCM literatures on the gastrointestinal heat retention syndrome, the syndrome is clearly recognized, confirming the definition of the gastrointestinal heat retention syndrome.This study took in 160 patients, with 80 people in each group.77 patients (96.25%) in the case group had gastrointestinal heat retention syndrome,3 patients (3.75%) didn’t; 41 patients (51.25%) in the control group had gastrointestinal heat retention syndrome,39 patients (48.75%) didn’t. The odds ration was 24.415 (95%C.I.7.108-83.856), suggesting that patients with gastrointestinal heat retention syndrome had 24.415 times more chance of an Hp infection.According to the "Gastrointestinal Heat Retention Integral Diagnosis Scale", patients in the case group was ranked, light gastrointestinal heat retention syndrome had 1 patient (1.25%), medium had 12 patients (15.00%),and heavy gastrointestinal heat retention syndrome had 64 patients (76.00%). This suggests that the chance of Hp infection increases with the ranking of gastrointestinal heat retention syndrome.DOB is the diagnostic standard for a positive 13C-urea breath test. When DOB is≥4 hours, Hp is considered a positive. When it is close to the threshold, the test results could be a false negative or positive. In this research, the Spearman correlation coefficient for the DOB value of the Gastrointestinal Heat Retention Syndrome is 0.856 (p=0.000), suggesting that a correlation exists between the syndrome and the DOB value.This research did an exploration on the correlation between the element of gastrointestinal heat retention syndrome and Hp infection. By using Logistic single factor analysis,18 related factors were selected, with 6 elements having a high correlation with Hp infection, respectively dry stool (OR=88.407, p<0.005), smelly stool (OR=28.895, p<0.005) yellow and dry tongue coating (OR=58.5, p<0.005), yellow and greasy tongue coating (OR=25.327, p<0.005), scorching stomach pain (OR=16.579, p<0.005), being light sleep (OR= 4.091, p<0.005).Conclusion:1 There is a high correlation between gastrointestinal heat retention syndrome and Hp infection.2 As the severity of gastrointestinal heat retention syndrome increases, so does the chance of Hp infection.3 Gastrointestinal heat retention syndrome related elements:dry stool, smelly stool, yellow and dry tongue coating, yellow and greasy tongue coating, scorching stomach pain, light sleep are all highly correlated with Hp infection.