A Literature Study On The Treatment Of Yellow Water Disease With Tibetan Medicine And Its Pharmacodynamics

Huang Water disease is a clinical symptom in Tibetan medicine theory to guide the variety of diseases, for the study of Tibetan Rheum nobile Hook.f.et.Thoms treat disease theory and experimental evidence, we conducted a literature yellow water Disease and Experimental Research.Literature studies have shown that Five Source, Three Core is the basics of Tibetan medicine. Tibetan medicine is a complete theoretical system and a good clinical efficacy of a discipline. Five Source is the Tibetan ancient materialist philosophy of simplicity, it believes all things in the universe by earth, water, fire, wind, air Primal five substances. Among them, the earth has a steady, heavy, cotton, tired (run), blunt, dry characteristics, fire thermal, dynamic, light, rough, dry, sharp features, water has a moist, wet, cold, thin, soft, blunt heavy features, the wind has moving, dry, light, astringent, cold, rough features, with an empty space and empty, accessibility features. Tibetan Three Core (Long, ChiBa,PeiGen) to Five Source for the foundation, Long has the wind characteristics. ChiBa has fire characteristics. PeiGen has the soil, water features. Long, ChiBa,PeiGen together with empty properties. Tibetan growth comes from Five Source, the soil is the origin of the drug growing, water is the juice of the drug growing, the growth of the fire is a drug source, wind power growth of the drug, the drug growing empty space. Pentatomic drug necessary for growth, indispensable, otherwise the drug can not grow, can not have the treatment of ailments.The generation of Huang Water is that food enters the stomach through the mouth, after Long, ChiBa and PeiGen’s digestion, absorption and divided into eating subtle and dregs. Eating subtle of diet become blood, the blood is divided into essence and dregs, the dregs of blood trash to bile inner parts, In gallbladder generated for bile, the essence of bile becomes into the Huang Water.It can spread to the body skin, bones and zang-fu organs, especially between the skin and joints in the body.Its physiological function is to nourish and moisten the body, maintain the whole body full of elasticity, safeguard joint movement.When the Three Core’s balance is destroyed, the quality or quantity of Huang Water changes, lead to disease. Huang Water Disease symptoms range can be expressed as intractable sores on the skin, eczema, skin rash; medical edema and ascites edema; skeletal system manifested as joint pain.Si Bu Yi Dian recorded that Qumazi has the function of reducing Huang Water and eliminating edema.Qumazi is the plants of Rheum L.. According to the function of plants of Rheum L., they can be divided into well, generally and poor. The well is Junzha. Its efficacy is relieving hot, bacon and poison; The generally is Quzha. Its efficacy is drainage method of hot and callus; The poor is Qumazi. It has the function of reducing Huang Water and eliminating edema. Descriptions of Qumazi in many Chinese version of Tibetan medicine books are different.Therefore, through investigations based on the ancient and modern Tibetan medicine literatures, experts’advice and field researches, confirmed thaTibetan Qumazi belongs to a class of plants of Polygonaceae Rheum, which are Rheum nobile Hook.f.et.Thoms, Rheum globulosum Gage, Rheum alexandrae Hook.f.et.Thoms, Rheum pumilum Maxim and Rheum delavayi Franch. In some regions, Rheum spiciformeRoyle and Rheum przewalskyi Losinsk are probably substitutes of Qumazi. However, authors turn out that it is wrong to use thePolygonum sibiricum Laxm as Qumazi.In Tibetan medicine, Qumazi is mainly used to treat Water Disease in clinical.Experimental aspects:According to the Rheum nobile Hook.f.et.Thomsin the application of Tibetan, to study the pharmacodynamics of it, we use extract of water, ethanol and ethyl acetate to study with anti-inflammatory, choleretic and diuretic. Itsaqueous extraction is 41.38%; ethanol extraction is 35.05%; ethyl acetate extraction is 12.03%.1 Experimental study of anti-inflammatory effectBy intraperitoneal injection of acetic acid in mice, mice ear swelling caused by xylene and rat chronic subcutaneous embedment tampon granuloma experimental methods, including observation tower, alcohol and acetic acid extract on capillary permeability in mice, mice ear swelling caused by xylene and its influence on cotton ball granuloma of rats.The ethanol extract (0.59g/kg,1.18 g/kg,2.36 g/kg), aqueous extract (0.69 g/kg,1.38 g/kg,2.76 g/ kg) and ethyl acetate extract (0.4 g/kg,0.2 g/kg) can significantly inhibit the increase of vascular permeability induced by acetic acid glacial (P<0.05, P<0.01);Aqueous extract (0.48 g/kg,0.96 g/kg,1.92 g/kg), ethanol extract (0.41 g/kg,0.82 g/kg) of rats with chronic granulomatous has significant inhibitory effect (P<0.05, P<0.01).2 Experimental study of gallbladderUsing the method of continuous administration theNormal ratsof four days, and then plug the bile duct hose, observation water, alcohol and ethyl acetate extracts influence on bile secretion in rats, the results:water, alcohol, ethyl acetate extract exhibit certain choleretic trend.3diuretic experimental study3.1 Water load testUsing water load test method, observation water, alcohol and ethyl acetate extracts on rat urine load of water, the result:large doses of ethanol extract (1.64 g/kg) and the aqueous extract (0.96 g/kg,1.92 g/kg) in the first 1h water load discharging rats having significant inhibition of urine (P<0.05, P<0.01).3.2 Aortic stenosis with water load testUsing rat aortic stenosis approach normal feeding 21 days after surgery, cardiac ultrasound passes rat ventricular systolic left ventricular wall thickness and the actual weight of the correction value increased significantly (P<0.05); the heart of rats produce pathological changes, combined with the water load test. As a result, a small dose (0.41 g/kg) of the ethanol extract in the first lnsignificantly promotes rat aortic stenosis leads to cardiac hypertrophy urine discharge (P<0.05). Large doses (1.64 g/kg) of ethanol extract, aqueous extract large doses (1.92 g/kg) have significantly inhibited rat urine discharge of this model (P<0.05, P<0.01) in the first 1,2h.4Anti-inflammatory mechanism studyBy intraperitoneal injection of 0.6% acetic acid, causing an increase in capillary permeability in mice, centrifuged blood, leaving the serum. Detection of water, the impact of ethanol extract of the inflammatory cytokines IL-1β, TNF-a, and the results ethanol extract (0.41 g/kg、0.82 g/kg、1.64 g/kg) and aqueous extract (0.48 g/kg、0.96 g/kg、1.92 g/kg) could significantly inhibit the secretion of IL-1β, and ethanol extract could significantly inhibit the secretion of TNF-a in (P<0.01).ConclusionHuang Water disease is a unique disease of Tibetan medicine. The imbalance of Three Corein Tibetan medicine is important. Huang Water can be expressed as modern medicine intractable sores, eczema, skin rashes; edema and ascites; joint pain and other diseases; Qumazi has the function of reducing Huang Water and eliminating edema. R.nobile Hook.f.et.Thoms is a source of Qumazi. Modern pharmacodynamics experiments showed that: Its aqueous extract, ethanol extract and ethyl acetate extract has effect against increased vascular permeability induced by acetic acid, against chronic granulomatous role, with anti-acute and chronic inflammation and to a certain extent gallbladder trends and diuretic, Which is basically consistent with the theoretical effect of Tibetan medicine. Its ethanol extract inhibits TNF-a, IL-1βsecretion, aqueous extract of it inhibiting the secretion of IL-1β Explain the R. nobileHook.f.et.Thoms anti-inflammatory mechanism may be associated with TNF-a, IL-1β. Through the above literature and experimental studies,provides a theoretical and experimental basis of the treatment of R. nobileHook.f.et. Thoms to research Huang Water Disease.