Analysis Of Clinical Data Of 80 Patients With Diabetic Nephropathy

Objective:Analyze and summarize the diabetic nephropathy general information, complications, diabetic retinopathy, distribution of traditional Chinese Medicine (TCM) symptoms, syndrome distribution and laboratory indicators, in order to explore the clinical characteristic of diabetic nephropathy, TCM syndrome distribution regularity and the difference in laboratory indicators between each syndrome, and to provide reference for TCM syndrome differentiation and treatment of diabetes nephropathy.Methods:80 cases of patients who were clinically diagnosed with diabetic nephropathy were recruited from Beijing Hospital during the year 2012 to 2014. SPSS 19.0 was used to analysis general information, complications, diabetic retinopathy, distribution of TCM symptoms, syndrome distribution and laboratory indicators. The measurement data use independent sample t-test and variance test. Chi-square test was used in enumeration data. After analysis, x士s and p were recorded. P<0.05 is considered statistically significant.Results:(1) Among the 80 cases, men are more than women.80 percent of the patients are the elderly. Patients with diabetes duration of ten years or more accounts for 78.18%. The patients whose diabetes duration between 10 to 19 years accounts for 50.0%. Only 27.5% patients’ weight is normal. The majority of patients of body weight are overweight or obese, accounted for 51.25% and 21.25% respectively.(2) The percentages of combining with dyslipidemia, hyper tension disease, coronary heart disease, cerebrovascular disease are 80.0%, 77.5%,45.0%,42.5%. All patients are combined with diabetic retinopathy, and giving priority to with background retinopathy (95.0%).(3) Deficient syndromes are mainly Qi and Yin deficiency, followed by the spleen and kidney Yang deficiency, liver and kidney Yin deficiency, Yin scorching is relatively rare. Excessive syndromes are mainly blood stasis syndrome, followed by damp-heat syndrome, phlegmy wet syndrome. The main compound type is qi and Yin deficiency with blood stasis. Stage Ⅳcompared to stage Ⅲ, patients with spleen and kidney Yang deficiency, damp-heat, phlegmy wet is in higher frequency.(4) The average of fasting glucose, glycosylated hemoglobin and triglyceride of the patients with diabetic nephropathy are significantly higher than normal. Stage Ⅳ compared with stage Ⅲ, the glycosylated hemoglobin and uric acid are higher (P< 0.05).(5) Blood uric acid qi and Yin deficiency syndrome is the highest, followed by the spleen-kidney Yang deficiency syndrome, liver-kidney Yin deficiency syndrome, and Yin scorching syndrome. And the difference is statistically significant (P< 0.05). There are no statistical differences between the rest of the indicators.Conclusions:(1) The elderly and patients with long duration of diabetes have high incidence of diabetic nephropathy, and most patients are overweight or obese. Diabetic retinopathy is closely related to the occurrence of diabetic nephropathy, but the stage is not completely corresponding. Most of the patients with diabetic nephropathy combine with hypertension and dyslipidemia.(2) The TCM syndromes of diabetic nephropathy are characterized by deficient root and excessive superficial. The main deficient syndrome is the Qi and Yin deficiency, followed by the spleen-kidney Yang deficiency, liver-kidney Yin deficiency and Yin scorching. The main excessive syndrome is the blood stasis syndrome, followed by damp-heat syndrome and phlegmy wet. Qi and Yin deficiency with blood stasis is the main syndrome types. And along with the progress, Yang deficiency, phlegmy wet and damp-heat are gradually increased.(3) Hyperglycemia, dyslipidemia and high uric acid hematic disease may be a risk factor for diabetic nephropathy development.(4) The correlation between syndrome distribution and laboratory index is unclear, further research with expanding samples is necessary.