| Background:Chronic glomerulonephritis,chronic nephritis for short,is a set of c1-inical syndrome such as hematuria,proteinuria,edema and hypertension with associa-ted with decreased renal function for the clinical manifestations of glomerular disea-se or not.The disease is divided into primary and secondary glomerulonephritis and the object of this study is the former.Chronic nephritis often onset hidden. With the pr-ogress of modern science and technology and the accuracy of inspection equipment the majority of patients are found that their check-up is abnormal during examination. In recent years.with the awareness of the disease increased and outpatient medical co-nsultations to increase,the early onset of this disease belongs to the young and middle-aged,which brings enormous psychological pressure to patients.With the progress of the diseaset.it will eventually develop into chronic renal function failure and need repl-acement therapy,and also bring huge economic burden to individual and the country. Modem medical treatments for the disease is limited.in the middle the disease without a clear and effective treatment,and ACEI or ARB drugs only have some therapeutic ef-fect.But the therapy effect is limited because the side effects often appear before the treatment.So the patient are not willing to take the medicine continuous.Traditional Chinese medicine has a long history for the treatment of chronic nephritis.There are many effective treatments to cure it,including liquid form,acupuncture and moxibust-ion,massage,qi gong etc.The old TCM experts’experience with many years clinical practice is a valuable resource,which needs us to mining,sorting and inheritance and makes much efforts to improve the curative effect in the clinical treatment of chronic diseases.So it is necessary to research the effect of Chinese medicine in the treatment of chronic nephritis. Prof.LV Renhe who is based on more than 50 years of clinical practice in diagnosis and treatment, who first puts forward the "Shen Luo Zheng Jia" theory.According to the theory of "ShenXu" and "ZhengJia" two aspects,we use the mothed of Bu "Shen Yi Qi"and "Hua Yu Tong Luo" to cure chronic glomerulonephritis.This study divided into two parts of literature review and clinical research.Literature Review:This part is mainly from the following aspects are discussed. The ancient physicians understanding of the disease,the modern doctors to discuss the disease,Professor Lv Renhe "Shenluo zhengjia" theory,treatment of Chinese me-dicine research progress of the disease.Objective:This research is Pro. Lv Renhe "12th Five Year Plan support topics",staging with standard of chronic kidney disease stage,as the "three type four syndrome" of dialectical method,Pro. LvRenhe "Shenluozhengjia" theory as the ins-truction,with Yiqibushen,Tongluosanjie Treatment cohort study of early and mid ch-ronic kidney disease,explore this method in the glomerular filtration rate,24h urine protein,urine protein in the urine,traditional Chinese medicine control aspects of the syndrome is valid.(The basic composition of prescription drugs:Raw radix astragali 30g, angelica 10g, poria cocos 30g, radix cyathulae 30g, sal via miltiorrhiza 30g, Ch-inese starjasmine 30g, winged euonymus twig 10g,cohosh 15g, Gordon euryale seed 30g, Cherokee rose 30g).Methods:60 patients with stage 1-3 chronic kidney disease patients were divided into exposure group (30 cases) and non-exposed group (30 cases),standardized collec-tion of clinical diagnosis and treatment information, based on objective diagnostic criteria dialectical type,exposure was observed before and after treatment groups TC-M syndrome score, in both groups laws for 24-hour urine protein,urine routine meas-urement,biochemical indicators,according to the relevant formula to calculate the glo-merular filtration rate, and finally the use of statistical software SPSS 17.0 statistical data.Results:l.Exposure group increased glomerular filtration rate after treatment,com pared with pre-treatment difference was statistically significant (P<0.05),the non-expo-sed group before and after treatment had no significant glomerular filtration rate chan-ge(P>0.05),the difference was not statistically significant.1. Compared with the group after treatment,the overall exposure group of glome-rular filtration rate raised gradually,and the differences were statistically significant (P<0.05).The difference between after the treatment 6 months and after the treatment 2 months was more obvious.The glomerular filtration rate in general of non-exposed group is on the decline, and no statistically significant differences before and after therapy (P>0.05).2. Compared with the group after treatment,the 24 hours urinary protein quan-titative of exposure group was reduced, which were statistically significant (P<0.05). The difference between after the treatment 6 months and after the treatment 2 months was more obvious; The 24 hours urinary protein of non-exposed group showed a tren-d of increase, and were statistically significant (P<0.05).3. The 24 urinary protein between exposure group and non exposed group bef-ore treatment were no obvious changes, the differences were not statistically signifi-cant(P>0.05).The difference after treaing 2 months had statistically significant(P< 0.001), and compared with 2months,after treating 6 months had more significantly differences, which had statistically significant(P<0.001).4. The exposed group in TCM syndrome score decreased significantly after tre-atment,statistically significant difference compared with before treatment(P<0.05).
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