Study On Anti - Oxidation And Anti - Aging Effects Of Bushen Yishou Tablet In

Senile is the irreversible loss in function of every cell and organ with the time goes by after the biological maturity, aging and corresponding mechanism is very complex, which is a biological process containing many links. Relevant scientific researches show that the occurrences of aging and related diseases such as cancer are closely related with the excessive free radicals, and antioxidant researches can minimize the damage by overcoming free radicals. Because of some properties such as safety, effectivity and the mild side effects, etc. Traditional Chinese medicine plays an important role in the aspects of antioxidant and anti-aging. Therefore, it will have good scientific value and market prospects to research and develop new anti-aging Chinese medicine which has mild side effects and curative effects.Bushen Yishou Pian is a Chinese patent medicine which is composed of epimedium, red ginseng, fleece-flower root, ganoderma lucidum, pearls, medlar, salvia miltiorrhiza, huang jing and licorice, and many component of this medicine has been reported with the effects of protect the kidneys, antifatigue and anti-aging.This experiment takes Bushen Yishou Pian as the raw material and measures its antioxidant capacity and anti-aging effect in vitro. The experiment is divided into two parts. The first part mainly discusses the functions of Bushen Yishou Pian to eliminate DPPH free radical, hydroxyl free radical (·OH), to protect DNA and provide relevant basis to the second part as well. As to the second part, it mainly discusses the effectivity that Bushen Yishou Pian on the D-galactose aging model mice about anti-aging in different doses (0.3,1.0,3.0mg/kg), and measures the weight gain rate, the spleen index, SOD, gsh-px, T-AOC and MDA in serum, SOD, gsh-px, T-AOC and MDA in liver tissue, MAO-B, SOD, T-AOC and MDA in brain tissue. From these indicators, we can be sure of the anti-aging effect of Bushen Yishou Pian.The results of the first experiment show:1. Bushen Yishou Pian has a good effect to clear DPPH free radical and hydroxyl free radical (·OH).2. Bushen Yishou Pian can effectively protect the DNA damage which caused by the peroxy radical (ROO-) and hydroxyl radical. The results of the second experiment show:1. Bushen Yishou Pian can effectively increase the growth rates and index of spleen of aged rats induced by D-galactose. It also showed that Bushen yishou pian can effectively alleviate the damage of aging and immune organs.2. Bushen Yishou Pian can significantly improve the activity of SOD, GSH-PX, T-AOC and decrease the levels of MDA in serum induced by D-galactose.3. Bushen Yishou Pian can significantly improve the activity of SOD,GSH-PX, T-AOC and decrease the levels of MDA in liver induced by D-galactose.4. Bushen Yishou Pian can significantly improve the activity of SOD,T-AOC and decrease the levels of MDA, inhibit the activity of MAO-B in brain, which avoid brain damage during the aging.In conclusion, some dose of Bushen Yishou Pian has strong functions of antioxidant and DNA protection in vitro and it can adjust the body metabolism, relieve the oxidative damage of organs and improve the anti-aging ability of mice through the removal of free radicals. Whether Bushen Yishou Pian also has anti-aging effect to human body or not, it deserves to be further researched.