The Effect Of Chinese Herbs Combined With α-ketoglutarate On The Gut And System Immunity In Weaned Rats

In present paper the effect of Chinese herbs combined withα-ketoglutarate (AKG)on gut and system immunity was studied in weaned rat randomly divided into three groups: Control group, herbs supplement group and Chinese herbs plus AKG supplement group, respectively. The fallowing items were tested: 1) the area and the number of Peyer's patches in the small intestine. 2) the duodenal IgA secretion. 3) the weight of immune apparatus. 4) the phagocytosis of macrophage. 5) the number of T-cells in the blood. 6) the hemolysin of B lymphocyte. 7) the indices of the hemogram. 8) the lymphocyte transformation.The results showed that the area of Peyer's patch in the small intestine was significantly bigger in both Chinese herbs fed and Chinese herbs plus AKG fed rats than control rats, though the number of Peyer's patch was not significant different among 3 groups. The concentration of duodenal IgA was significantly higher in Chinese herbs plus AKG fed rats compared with control ones. Chinese herbs plus AKG increased the concentration of serum globulin and immunoglobulin. The cellular and hormonal immunity in Chinese herbs and Chinese herbs plus AKG fed rats were promoted.The spleen coefficient showed that the growth of spleen in Chinese herbs and Chinese herbs plus AKG fed rats was facilitated. The number of red and white blood cells was not significant different in 3 groups. It indicated that the supplement of herbs and AKG doesn't worsen the function of the rat organism. In addition, the supplementation of Chinese herbs combined with AKG is more effective in the improvement of the gut and the system immunity than the supplementation of Chinese herbs alone.