Friedel-Crafts Acylation Under Microwave Irradiation And Solvent-free Conditions And Deprotection Of Acyl-group With Thionyl Chloride

Studies on Friedel-Crafts acylation under microwave irradiation and solvent-free conditions and deprotection of amino group with thiony chloride were carried out. Satisfactory yields were obtained. This thesis consists of four chapters:Chapter 1: PrefaceChapter2: With the mixture of phosphoric acid and pentoxide (85 %H3PO4/P2O5) as catalyst, phenol and its derivatives reacted together with carboxylic acids to produce aromatic hydroxyketones by one-pot reactions under microwave irradiation and solvent-free conditions. Compared with the classic two-step synthesis, it only need 1-5 min and has an advantage of low cost, easy disposal and less pollution.Chapter3: 4-(Acetylamino)-γ-oxobenzenebutanoic acid was synthesized from succinic anhydride and acetanilide with ZnCl2 as catalyst under microwave irradiation and solvent-free conditions. This course was simple and clean. When the molar ratio was 1:1.5, the power was 385 W and the reaction time was 5 min, the yield got up to 72.3 %.Chapter 4: With 1,2-Dichloroethane as solvent and pyridine as catalyst, the amino protection group of amide was removed by thionyl chloride via chlorination and hydrolysis. This reaction was completed in 4-6 h at room temperature and possessed features of simple, mild and easy purification.