The Synthesis And Characterization Of Water-soluble Compound Containing Branched Structure

As the Porphyrin and Perylene diimide of the light center, we designed and synthesized two kinds of water-soluble compounds containing branched structure by introducing the PEO and dendritic peptide as the lyotropic groups respectively. We also studied the affection of the molecular structure on the UV and fluorescence properties. The details are as follows:1,Porphyrins(1) 4- carboxyphenyl porphyrin and 8- carboxyphenyl porphyrin were modified by branched hydrophilic PEO chain to synthesize two kinds of water-soluble porphyrins.(2) The spectroscopy properties of two porphyrin compounds in water and organic solvents were investigated by fluorescence and UV spectra, which shown they have no obvious aggregation behaviors in the water. And there was no difference in their fluorescence quantum efficiency.(3) The singlet oxygen yields of the porphyrin compounds are 0.74 and 0.93, respectively.(4) The biocompatibility and cytotoxicity of two porphyrins were evaluated for cell experiment.The experiment groups without irradiation showed good biocompatibility; while they showed superior cytotoxicity by submitting to irradiation.2,Perylene diimide(1) The first, second generation of amphiphilic dendritic peptide were synthesized with yield over 70%.(2) The first generation of four carboxyl group Perylene diimide was synthesized by introducing the L- aspartic acid ,which have certain water solubility. We also synthesized the second and third generation of carboxyl group Perylene diimide compounds continuously, which have good water solubility.(3) The water-soluble Perylene diimide compounds were characterized in DMSO by using fluorescence and UV spectra. The results showed that the aggregation was patially suppressed.