Studies On The Structural Modification Of Pseudo-ginsenoside-F₁₁

Pseudo-ginsenoside-F11 was first discovered in Panax quinquefolium L.. It is the characteristic ingredient in Panax quinquefolium L..Modern pharmacology study shows that Panax quinquefolium L. has many pharmacological activities, its main active ingredient is ginsenosides. At present ginsenosides isolated from genus of Panax can be divided into five types:protopanaxadiol type ginsenosides, protopanaxatriol type ginsenosides, ocotillol type ginsenosides, oleanic acid type ginsenosides and the other type. Pharmacological research shows that ginsenosides have many pharmacological activities like improving immune function, anti-aging and anti-fatigue, adjusting the central nervous system, adjusting endocrine system, pharmacological anti-tumor, etc.Ocotillol ginsenosides are the characteristic components of Panax quinquefolium Land these are different from the panax. Currently ocotillol ginsenosides are also found in other genus of Panax, Vietnam Panax, beads panax, bamboo panax. etc. Ocotillol ginsenosides pharmacological research mainly in the following aspects:(1) Ocotillol ginsenosides have antagonism of morphine physical, psychological dependence and antagonistic effects of methamphetamine neurotoxicity; (2) Protection of the role of cardiovascular and cerebrovascular systems; (3) Protection the nervous system, promoting wisdom and preventing dementia. In order to further development ocotillol ginsenosides, this thesis reviews ocotillol ginsenosides chemical constituents and pharmacological activities research progress. And with pseudo-ginsenoside F11 isolated from the leaves of Panax quinquefolium L. as raw materials studied the products under acid condition.In order to further study on the Ocotillol ginsenosides and prepare quantity of low content, we studied the products of pseudo-ginsenoside F11 degradation in acidic condition by using the chromatography and recrystallization etc.And five compounds were isolated from the acid degradation products. Four of the five compounds were identified by the spectral methods including'H-NMR,13C-NMR and IR etc.They are (12R,20S,24S)-20,24: 12,24-diepoxy-dammarane-3β. 6α-diol(Ⅰ),24(R)-Ocotillol(Ⅲ),20(R),24(R)-Ocotillol(Ⅳ) and 6-O-β-D-glucopyranoside-dammar-20(S).24(R)-epoxy-3β. 6α,12β,25-tetraol(Ⅴ).In summary, all the results of the studies presented here may provide credible foundation for new drugs and further study.