Investigations On Drug Inclusion Complexes By β-Cyclodextrin Derivatives And Their Analytical Applications

β-Cyclodextrin (β-CD), as the second generation supramolecular compound, has a very wide application in many fields.β-cyclodextrin posses a hydrophilic exterior, hydrophobic interior and the cavity size ofβ-CD is 7.8 A. So, Various guest molecules which with suitable polarity and dimension can be encapsulated into the cavity ofβ-cyclodextrin.β-Cyclodextrin can be used to improve the physical, chemical and biological properties of guest molecules. In the field of pharmaceutical,β-cyclodextrin is considered to be the ideal material to overcome some undesirable properties of drug through formation inclusion complexes with drug. After the formation ofβ-cyclodextrin inclusion complex, some physical and chemical properties of drug molecules, such as stability, solubility and bioavailability will be significant improved at some extent.In order to get drug carrier whose properties are better than natural B-cyclodextrin, it is very necessary to modifyβ-cyclodextrin.β-CD's hydroxyl groups as a starting point for structural modification, a variety of different functional groups can be introduced into B-cyclodextrin molecules to further improve its physical and chemical properties. Modified B-cyclodextrins, namely,β-cyclodextrin derivatives.In summary, B-cyclodextrin as well asβ-cyclodextrin derivatives play signification roles in field of medicinal chemistry to modify some undesirable properties of drug.Two aspects of innovative ideas were performed in this paper:1. The study on twoβ-CD derivatives and drugs inclusion complexes by spectrofluorimetry. After the formation of inclusion complexes, the nature of the drugs' fluorescence spectrum has been improved and their water solubility has been enhanced.2. The study on supramolecular system were carried out by spectrofluorimetry, on the base of the great enhancement of the fluorescence intensity of drugs molecules, spectrofluorimetric methods were established to determine them in real samples.This dissertation consists of three chapters:Chapter 1:Introduction. This part generally describes the structural characteristics as well as physical and chemical properties ofβ-CD, preparation and classification of modified cyclodextrin, preparation methods and characterization tools of drugs inclusion complexes and the applications ofβ-CD andβ-CD derivatives.Chapter 2:The fluorimetric investigation of supramolecular system by modifiedβ-cyclodextrin and its analytical application. Investigation on a new drug inclusion complex by modifiedβ-CD, and then the spectrofluorimetric method was used to determine mefenamic acid in in tablets, human serum and human urine.Chapter 3:The investigation on a host-guest inclusion system byβ-cyclodextrin derivative and its analytical application. Studies on mangiferin inclusion complex by modifiedβ-CD, the supramolecular system ofβ-CD derivative with mangiferin was studied by fluorescence spectra, and then the spectrofluorimetric method was used to determine mangiferin in human serum.