Synthesis, Crystal Structure, Characterization And Property Study Of Novel P-Tolualdehyde Secondary Amine Complexes

In recent years, transition metal complexes have attracted much attention because of their functional diversity. The effect of Schiff base metal complexes and the role of biological macromolecules, especially with the manner and mechanism of DNA interaction, the interaction with HSA type and pattern, are of great inortance in the field of cantineoplastic pharmaceuticals, molecular biochemistry and bioengineering technology. However, a disadvantage is that Schiff base ligands will be changed unstable in acid solution, the Schiff base ligands could be decomposed. To avoid the instability, reducing the imine (-CH=N-) group to the secondary amine (-CH2-NH-) is a good scheme. Not only the secondary amine is more stable than imines, but also it exhibits more flexible and is unconstrained to keep one coordination planar and the integrity of the molecular structure, which may also decrease the space steric hindrance and make the aryl residue in the complex easy to insert into groups between the biomacromolecule. Study on the growning of single crystal to make sure the structure of complexes. Design, synthesis the fluorescent sensor to distinguish from the small molecular solven. In addition, we tried to find a fluorescent sensor which recognized small molecule, and studied the process of single crystal to single crystal.This dissertation consists of four chapters:Chapter 1:A brief review of the research of the metal complexes. The structureand function, nature, mechanism of crystal growth and research methods of DNA and HSA, and prospects and applications of fluorescence probe Schiff bases complexes.Chapter 2:Synthesised a novel ligand(L), (N,N'-bis(4-methylbenzyl)ethane-1,2-diamine), and its transition metal(Ⅱ) complex, [ML2(H2O)2]2+·2NO3-, (M=Cu(Ⅱ), Co(Ⅱ), Ni(Ⅱ), Zn(Ⅱ)), have been synthesized and characterized by elemental analysis, IR and 1HNMR. The crystal structure of the Cu-L complex was characterized by X-ray single crystal diffraction, the results showed a regular octahedral structure in which each metal ion is six-coordinated with four nitrogen atoms from two ligands and two oxygen atoms from two water molecules. The interaction of the complex with calf thymus DNA and human serum albumin (HSA) were investigated by UV spectroscopy and fluorescence spectroscopy, and the results suggest that the complex binds to DNA and HSA by electrostatic interaction mode.Chapter 3:Exploratory study on the reaction of single crystal to single crystal, the metal ion Cu(Ⅱ) in place of the Cd(Ⅱ) in the single crystal. In application of fluorescent materials, after further study it can control the fluorescen absorbance.Chapter 4:Tried to synthesis three tpyes Cd(Ⅱ) complexes and their single crystals, CdCl2-L, CdSO4-L, Cd(NO3)2-L. By X-ray diffraction to determine and analysis the crystal structure, The same cation of differernt negative ions complexes were the observed fluorescence effects by solid surface fluorescence. studied on luminescence effects of the different small molecula and Concentration, to find a complex recognized small molecule as fluorescent sensor.