Synthesis Of ,7,12,18-Tetram Ethyl-13,17-Di(3-Disulfidepropyl) Porphyrin And Study Of The Biomimetic Catalytic Activities

Since 1921s Fischer winning the Nobel Prize synthesis of hemin derivatives, much attention have been focused on the porphyrins, especially in biomimetic oxidation reactions. Metalloporphyrins would be the best potential catalyst due to oxidation the unactivated C-H bonds of hydrocarbons. However, the high efficient selectivity and catalytic activities of Metalloporphyrins continues to be a challenge of the industrial chemistry.In this thesis, we prepared various metalloporphyrin derivatives by means of modification on naturally easily derived heme, which were applied to catalyse cyclohexane to investigate the catalytic activity. In order to improve selectivity and yield of product, we have designed and prepared metalloporphyrins. Because the structure of deuteronporphyrin is more relate the prosthetic group of cytochrome P450. Then, study the biomimetic catalytic activity of the metallodeuteroporphyrin derivatives should be helpful to develop and design the new and effective catalysts for oxidation.In the paper, Firstly, deuteroporphyrin were prepared from hemin by six steps including demetalation, esterification, reduction, bromization and sulfuration, finally, which reacted with metal salt synthesis of metalloporphyrin. The catalytic activity of the metallodeuteroporphyrins contain dithiol bond have also been studied in the oxidation of cyclohexane with air. The results show that the catalytic activity has been evidently improved in comparison with others metalloporphyrins. The mechanism of catalytic activities has also been studied in detail...