Design Syntheses And Superoxide Dismutase Activity Of Transition Metal Complexes With Schiff Bases

Since 1864,H.Schiff synthesized Schiff bases at the first time. In recent year, much interest has been focused on the Schiff bases and their mental ion complexes. Schiff base complexes which include the group of C=N are formed through the condensation of aldehydes or ketones with primary amines. The Schiff base complexes usually contain O, N and some other donor atoms, which easily form versatile complexes with metal ions. On its hybridization orbit's N atom which has orphaned to the electron has entrusted with in its important chemistry and the biology significane. The Schiff base complexes have been received much attention and have been widely used in many fields, such as catalysis, magnetic materials, biological activity and many other fields.Superoxide dismutase (Superoxide Dismutase, SOD) is important oxygen elimination in the organism, which can balance the oxygen radicals, and avoid the negative effects of the high concentration of the oxygen radicals. Moreover, the SOD is a valuable officinal enzyme. However, the natural SOD is difficult to extract and is very expensive. The modeling of the natural SOD by using the small molecule compounds becomes a hot research field. But the simulations have much defect when compared with the natural SOD. Much work needs to be done to model the natural SOD.In this paper, some Schiff base ligands derivecd from salicylaldehyde and its derivatives and their transition metal complexes have been synthesized. The influence of the reaction conditions, proportion of the starting materials, solvents, anions, bridging groups, etc. on the structures of the complexes have been investigated. Following, some of the complexes have been tested by NBT illumination method for their effect on the biological activity of imitating superoxide dismutase. The major work on the thesis is as following:(1) Nine Schiff base ligands of salicylaldehyde containing different substituent groups and their copper, zinc and nickel complexes were synthesized, and characterized by X-ray single crystal diffraction, IR spectroscopy and elemental analysis measurements.(2) Schiff base ligands according to the proportion of the amount of substituted salicylaldehydes and amines (2:1) and their copper, zinc disnucleus complexes were synthesized and characterized by X-ray single crystal diffraction, IR spectroscopy and elemental analyses.(3) The Cu-Zn dinuclear complexes were tested by NBT illumination method for their effect on biological activity of superoxide dismutase. Investigation indicated that some of the complexes have better biological activity.