The Synthesis Of Novel Thiazolidone And Acylthiourea Derivatives

Thiazolidone derivatives also have very important physiological activities, and they can be used as a fungicide, radiation sensitizing agents, antihypertensive drugs and diabetes.Acylthiourea, 1,2,3-triazole, and 1,3,4-thiadiazole derivatives have special physiological activities, such as relaxing blood vessels, anticancer, antivirus and antispasm. It has become a new hot spot in studies of azole compounds. The studies in recent years have shown that introducting the 1,2,3-triazole-based to some active molecules can significantly improve the biological activity of matrix elements.According to the principle of superposition activity, in this article, we have synthesized a series of thiazolidone and acylthiourea derivatives which are not reported in the literature by introducting 1,2,3-triazole-based, 1,3,4–thiadiazole and dibenzo into acetyl-hydroxy acyl thiazolidoneand thiourea derivatives through the promotion of ultrasonic radiation. This can provide leading compounds for new drug screening.Because of simple operation, mild reaction conditions, short reaction time, higher yield, the development of Ultrasonic radiation in the organic synthesis research has been very fast in recent years.This thesis consists of two major parts:The first part is about literature review. The principle and application of ultrasonic irradiation in organic synthesis were simply introduced. Furthermore, it symtematically expounded the research progress of thiazolidone derivatives, thiourea derivatives, 1,2,3-triazole, 1,3,4-thiadiazole and benzilic acid compounds.The second part is experimental content.1.4-(2-phenyl-1,2,3-triazol-4-yl)-5,6-dihydro-5-oxo-6-arymethylidene-thiazol-[2,3-c][1,2,4]triazole were synthesized by Ultrasonic radiation.2. N-aroyl-N′-[5-(2-phenyl-1,2,3-triazol-4-yl)-1,3,4-thiodiazol-2-yl]thioureas derivatives were synthesized by Ultrasonic radiation.3. N-aroyl-N′-(2-hydroxy-2,2-diphenylacetamido) thioureas derivatives were synthesized by Ultrasonic radiation...