Study On Ibuprofen, Pseudoephedrine Hydrochloride And Chlorphenamine Maleate For Suspension

Common cold in children is a common disease that seriously threatens the children's healthy. To choose a reasonable prescription to control the symptom of common cold and a proper formulation for children is important for the development of the children's coldrex. American Wyeth consumer's health company had developed a series of new coldrex--the Advil series. One of them was oral suspensions developed for children, with the brand name of"Children's Advil Allerey Sinus Suspension", which has exact therapeutic effect, less adverse reactions and easy to accept by children. This medicine was widely used in children's common cold treatment. In this article, a new product had been developed by changing the formulation according to the prescription of the Advil series coldrex, which called Pseudoephedrine Hydrochloride and Chlorphenamine. Maleate for Suspension. The prescription is consists of Brufen 200mg, pseudoephedrine hydrochloride 30mg, chlorpheniramine maleate 2mg per sack.Using orthogonal design test, the suspension agent was selected and the prescription was optimized. According to the related rules and standards, the quality standard and packaging standard were established. According to the standards, three bathes of samples were produced. Making use of three batches of samples,6-months accelerated-tests and 6-months long-term stability tests were finished. The results show that the quality of this medicine is stable under the packaging standard, and the packaging standard is satisfied to storage and transport.In a whole, Ibuprofen-Ephedrine-Chlorphenamini Maleas Chlorpheniramine Suspensions can effectively control the cold symptom and be applicable to the children. The prescription is reasonable, the quality is stable. In the future, the medicine will be extensively applied in treatment of children's cold.