Study On The Synthesis Of (Ferrocenyl)(Phenyl)methane Derivatives And N-heterocycle Derivatives

The thesis is mainly composed of two parts. The first part focus on the reaction of (ferrocenyl)(phenyl)methanol with nucleophiles such as indoles and arylamine. The second part is based on the synthesis of N-heterocycle derivatives.In the first section, the neucleophilic substitution reaction of (ferrocenyl)(phenyl)methanol with indoles were investigated, a variety of indole derivatives could be easily synthesized under the ultrasonic condition. The reaction is mild, manipulated easy and even afford high yields in short time. In addition, we focus on the reaction of amination of (ferrocenyl)(phenyl)methanol. In the presence of Ceric nitrate ammonium (CAN), (ferrocenyl)(phenyl)methanol react with arylamines quickly, affording the product of N-alkylation. Condition of the reaction is tender and the yield is good.In the second section, we synthesized a series of quinoline derivatives with 3-(arylamino)-5,5-dimethylcyclohex-2-enone and 2-chloro or 2-bromobenzaldehyde via Buchwald-Hartwig coupling followed by the intramolecular cyclization. The substituent group of halogen at the o-position of formyl in the substrate has great affect on the reantion.we synthesized a series of 2,4,5-trisubstituted imidazole derivatives through three-component one-pot reaction from substrates of cyanopyridine, aldehyde and ammonium acetate. The method is simple and feasible, however, it has some defects such as substrates limitation and low yields. Presently we are attempting to improve the yield and working on the mechanism of the reaction.