Study On Synthetic Method Of A Kind Of Phacolysin

The phacolysin easily enter crystal in vivo through the organization, may dissolve the protein to the crystal to have the greatly strengthened endophilicity, prevented the quinone type material causes the crystalline lens oxidation denaturation and even muddy, also can activate in Fang Shui the protein hydroltyic enzyme, urges the crystalline lens already muddy denatured protein decomposition absorption.Is one kind of very effective prevention and treats cataract drugs. The main process of synthesis is: First step is joins the neighbouring phenylene diamine the water and the hydrochloric acid water-soluble fluid makes the neighbouring phenylene diamine muriate; Again joins the iron trichloride solution room temperature response over night, pulls out filters produces 2,3- two aminos thickly fen qin, after the boiling water heavy crystallization pulls out filters the laundering dry. The second step synthesis is the neighbouring phenylene diamine joins the first step product 2,3- diaminos fen qin in the benzonitrile alcoholic solution the backflow 14 hours, pulls out filters produces 5,12- dihydro - 5,7,12,14- eraazapentacene thickly, produces 5,12- dihydro - 5,7,12,14- teraazapentacene with the boiling water heavy crystallization purely. The third step synthesis is 5,12- dihydro - 5,7,12,14- eraazapentacene and the mercuric sulfate joins the fuming sulfuric acid sulfonation reaction to produce 5,12- dihydro - 5,7,12,14- eraazapentacene 2,9- disulfonic acid.Again uses the sodium chloride salifying to respond the generator method to be possible the forest. This article might the forest synthesis craft conduct the research to the law, used the synthesis technical process was simple, raw material was easy moreover the production rate to be high, carried on the industrialization production suitably. Key word: The synthesis, the phacolysin, the purification...